ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneuhpC

inner membrane protein sensing glucose 6-phosphate

Protein ChangeF384L

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disruption of G6P-mediated induction of uhpT expression
Resistance To: Fosfomycin
Organisms: Escherichia coli
Papers: 1

Paper Information1

Novel Chromosomal Mutations Responsible for Fosfomycin Resistance in Escherichia coli.

PMID 33193186 · 2020

The mutation F384L in uhpC was associated with a 128-fold increase in fosfomycin MICs and conferred resistance. The mutation was validated by site-directed mutagenesis and observed in E. coli.

Mutation Information

uhpC: p.F384L

Protein Change: F384L
Organisms: Escherichia coli
Confers Resistance To

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Mutation Information