grlA
Overview
- Drug Classes
- levofloxacin, quinolones, fluoroquinolones, ciprofloxacin, enrofloxacin, ciprofloxacin|levofloxacin
- Organisms
- Staphylococcus aureus, Staphylococcus pseudintermedius, Staphylococcus haemolyticus +3 more
- Papers
- 8
- Mutations
- 17
| Nucleotide Change | Protein Change | Type | Effect on Function | Resistance To | Year | Paper | Status |
|---|---|---|---|---|---|---|---|
| - | S80F | - | - | levofloxacin | 2010 | Impact of recA on levofloxacin exposure-related resistance development. PMID: 20660686 | Not Validated |
| - | S80F | - | - | quinolones | 2001 | Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. PMID: 11709337 | Not Validated |
| - | S80F | - | - | fluoroquinolones | 2002 | Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations. PMID: 11751133 | Not Validated |
| - | S80F | - | - | ciprofloxacin | 2001 | Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance. PMID: 11600359 | Not Validated |
| - | S80F | - | reduced the potency of ciprofloxacin | quinolones | 2001 | Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates. PMID: 11257024 | Not Validated |
| - | D84N | - | - | enrofloxacin | 2008 | Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius. PMID: 18305127 | Not Validated |
| - | S80I | - | - | enrofloxacin | 2008 | Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius. PMID: 18305127 | Not Validated |
| - | S80F | - | - | ciprofloxacin|levofloxacin | 2010 | Skin lesion caused by ST398 and ST1 MRSA, Spain. PMID: 20031071 | Not Validated |
| - | V82L | - | - | levofloxacin | 2010 | Impact of recA on levofloxacin exposure-related resistance development. PMID: 20660686 | Not Validated |
| TCT->CTT | S80L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| TCT->CTT | S84L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| TCT->CTT | S84L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| TCT->CTT | S80L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| TCT->CTT | S84L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| TCT->CTT | S80L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| TCT->CTT | S84L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| TCT->CTT | S80L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
Impact of recA on levofloxacin exposure-related resistance development.
PMID 20660686 · 2010A point mutation (S80F) was encoded in grlA, despite exhibiting a susceptible phenotype.
Mutation Information
- Gene Name
- grlA
- Protein Change
- S80F
Confers Resistance To
Organisms Observed In
Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.
PMID 11709337 · 2001Mutation Information
- Gene Name
- grlA
- Protein Change
- S80F
Confers Resistance To
Organisms Observed In
Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.
PMID 11751133 · 2002Mutation Information
- Gene Name
- grlA
- Protein Change
- S80F
Confers Resistance To
Organisms Observed In
Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance.
PMID 11600359 · 2001Mutation Information
- Gene Name
- grlA
- Protein Change
- S80F
Confers Resistance To
Organisms Observed In
Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.
PMID 11257024 · 2001Mutations promoted from gene entry 'grlA' (model emitted mutations_found inside genes).
Mutation Information
- Gene Name
- grlA
- Protein Change
- S80F
Effect on Function
reduced the potency of ciprofloxacin
Confers Resistance To
Organisms Observed In
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
PMID 18305127 · 2008Mutation Information
- Gene Name
- grlA
- Protein Change
- D84N
Confers Resistance To
Organisms Observed In
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
PMID 18305127 · 2008Mutation Information
- Gene Name
- grlA
- Protein Change
- S80I
Confers Resistance To
Organisms Observed In
Skin lesion caused by ST398 and ST1 MRSA, Spain.
PMID 20031071 · 2010Mutation Information
- Gene Name
- grlA
- Protein Change
- S80F
Confers Resistance To
Organisms Observed In
Impact of recA on levofloxacin exposure-related resistance development.
PMID 20660686 · 2010A point mutation (S80F) was encoded in grlA, despite exhibiting a susceptible phenotype.
Mutation Information
- Gene Name
- grlA
- Protein Change
- V82L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- grlA
- Nucleotide Change
- TCT->CTT
- Protein Change
- S80L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- grlA
- Nucleotide Change
- TCT->CTT
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- grlA
- Nucleotide Change
- TCT->CTT
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- grlA
- Nucleotide Change
- TCT->CTT
- Protein Change
- S80L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- grlA
- Nucleotide Change
- TCT->CTT
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- grlA
- Nucleotide Change
- TCT->CTT
- Protein Change
- S80L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- grlA
- Nucleotide Change
- TCT->CTT
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- grlA
- Nucleotide Change
- TCT->CTT
- Protein Change
- S80L