Overview
- Mechanism
- reduced the potency of ciprofloxacin
- Resistance To
- quinolones, fluoroquinolones, ciprofloxacin, ciprofloxacin|levofloxacin, levofloxacin
- Organisms
- Staphylococcus aureus
- Papers
- 6
Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- quinolones
- Source Database
- Reslit
Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- fluoroquinolones
- Source Database
- Reslit
Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- ciprofloxacin
- Source Database
- Reslit
Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.
Mutations promoted from gene entry 'grlA' (model emitted mutations_found inside genes).
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- quinolones
- Effect on Function
- reduced the potency of ciprofloxacin
- Source Database
- Reslit
Skin lesion caused by ST398 and ST1 MRSA, Spain.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- ciprofloxacin|levofloxacin
- Source Database
- Reslit
Impact of recA on levofloxacin exposure-related resistance development.
A point mutation (S80F) was encoded in grlA, despite exhibiting a susceptible phenotype.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- levofloxacin
- Source Database
- Reslit
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