pbp2b
penicillin-binding protein 2B
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to pbp2b
AMR Rules
Browse AMR rules for pbp2b
Validation StatusCandidate
Overview
- Mechanism
- mutation-induced resistance
- Validation Method
- transformation experiments with cloned pbp genes
- Drug Classes
- amoxicillin
- Organisms
- Streptococcus pneumoniae
- Geographic Location
- France|Hungary
- Papers
- 4
- Databases
- Reslit
- Mutations
- 6
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| T599Q | - | - | Streptococcus pneumoniae | amoxicillin | Reslit | Candidate |
| T598R | - | - | Streptococcus pneumoniae | amoxicillin | Reslit | Candidate |
| T446A | - | - | Streptococcus mitis, Streptococcus pneumoniae | beta-lactampenicillin | Reslit | Candidate |
| A619G | - | - | Streptococcus mitis | beta-lactam | Reslit | Candidate |
| T445A | - | - | Streptococcus pneumoniae | amoxicillin | Reslit | Candidate |
| T567I | - | - | Group B | penicillin | Reslit | Candidate |
Papers4
1
Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin.
The study identifies mutations in penicillin-binding protein genes (pbp2x, pbp2b, pbp1a) and the murMN resistance determinant as contributors to amoxicillin and penicillin resistance in Streptococcus pneumoniae isolates.
Gene Information
- Gene Name
- pbp2b
- Allele
- pbp2b
- Encodes
- penicillin-binding protein 2B
- Source Database
- Reslit
- Mechanism
- mutation-induced resistance
- Confers Resistance To
- amoxicillin
- Organisms Tested In
- • Streptococcus pneumoniae
- Geographic Location
- France|Hungary
- Validation Method
- transformation experiments with cloned pbp genes
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