Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| - | - | Mycobacterium tuberculosis | para aminosalicylic acid | ResFinder Database | Established | ||
| - | - | Mycobacterium tuberculosis | para aminosalicylic acid | ResFinder Database | Established | ||
| - | - | Mycobacterium tuberculosis | para aminosalicylic acid | ResFinder Database | Established | ||
| - | - | Mycobacterium tuberculosis | para aminosalicylic acid | ResFinder Database | Established | ||
thyA thymidylate synthase | 264fs | - | - | Mycobacterium tuberculosis | para aminosalicylic acid | Reslit | Candidate |
thyA thymidylate synthase | 39fs | - | - | Mycobacterium tuberculosis | para aminosalicylic acid | Reslit | Candidate |
thyA thymidylate synthase | A113G | - | - | Mycobacterium tuberculosis | trimethoprim | Reslit | Candidate |
thyA thymidylate synthase | A114V | - | - | - | para aminosalicylic acid | Reslit | Candidate |
thyA Thymidylate synthase A | A182P | - | The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms. | Mycobacterium tuberculosis | para aminosalicylic acid | Reslit | Candidate |
thyA Thymidylate synthase A | C146R | - | The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms. | Mycobacterium tuberculosis | para aminosalicylic acid | Reslit | Candidate |
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