Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
thyA	G91R	-	single resistance variant	Mycobacterium tuberculosis	para aminosalicylic acid	Card DatabaseResFinder Database	Confirmed
thyA	H207R	-	single resistance variant	Mycobacterium tuberculosis	para aminosalicylic acid	Card DatabaseResFinder Database	Confirmed
thyA thymidylate synthase	H75N	-	single resistance variant	Mycobacterium tuberculosis	para aminosalicylic acid	Card DatabaseResFinder DatabaseReslit	Confirmed
thyA Thymidylate synthase A	L143P	-	The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms.	Mycobacterium tuberculosis	para aminosalicylic acid	Reslit	Candidate
thyA Thymidylate synthase A	L172P	-	The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms.	Mycobacterium tuberculosis	para aminosalicylic acid	Reslit	Candidate
thyA thymidylate synthase	L214Q	-	-	Staphylococcus aureus	trimethoprim sulfamethoxazole	Reslit	Candidate
thyA thymidylate synthase	L2Q	-	-	Staphylococcus aureus	trimethoprim sulfamethoxazole	Reslit	Candidate
thyA thymidylate synthase	L2W	-	-	Staphylococcus aureus	trimethoprim sulfamethoxazole	Reslit	Candidate
thyA thymidylate synthase	N92K	-	-	Staphylococcus aureus	trimethoprim sulfamethoxazole	Reslit	Candidate
thyA	P224L	-	single resistance variant	Mycobacterium tuberculosis	para aminosalicylic acid	Card DatabaseResFinder Database	Confirmed