Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
acrB efflux pump component	Q176K	C527A	increases binding energy for cefotaxime, improving recognition in the distal binding pocket, multidrug efflux RND transporter permease subunit AcrB	Salmonella typhimurium, Salmonella enterica	cefotaximecephalosporins	Reference Gene CatalogReslit	Confirmed
acrB	R620C	-	multidrug efflux RND transporter permease subunit AcrB	Escherichia coli	tigecycline	Reference Gene Catalog	Established
acrB AcrB, the substrate-binding domain of the AcrAB-TolC system	R620S	-	hypersusceptibility toward ampicillin and colistin	Salmonella typhimurium	phenicolsampicillin	Reslit	Candidate
acrB AcrB protein	R653H	-	-	Francisella novicida, Francisella tularensis	ciprofloxacindoxycyclinephenicols	Reslit	Candidate
acrB efflux pump component	R716L	-	-	Klebsiella pneumoniae	ceftazidime avibactam	Reslit	Candidate
acrB efflux pump	R717L	C2150T	reduces steric barriers associated with transit through the substrate channel 2 of AcrB, Target modification, multidrug efflux RND transporter permease subunit AcrB	Salmonella Typhi, Escherichia coli, Salmonella enterica, Salmonella typhimurium	azithromycinmacrolidesfluoroquinolones+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
acrB component of the AcrAB efflux pump	R717Q	G2152A	increases AZI efflux in the acrAB-TolC efflux pump, Target modification, multidrug efflux RND transporter permease subunit AcrB	Salmonella Typhi, Salmonella enterica, Escherichia coli, Salmonella Paratyphi	azithromycinmacrolidesfluoroquinolones+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
acrB Multidrug efflux pump RND permease	S665A	-	-	E. coli	tetracycline	Reslit	Candidate
acrB multidrug efflux pump	S966A	-	-	Klebsiella pneumoniae	tetracyclinecefoxitin	Reslit	Candidate
acrB multidrug efflux pump	T104A	-	-	Escherichia coli	phenicolserythromycin	Reslit	Candidate