Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ampC AmpC β-lactamase	F121L	-	enhanced cephalosporin resistance	Pseudomonas aeruginosa	ceftazidimeceftolozaneceftolozane tazobactam	Reslit	Candidate
ampC beta-lactamase	F147L	-	-	Pseudomonas aeruginosa	ceftolozane tazobactamceftazidime avibactamceftolozane	Reslit	Candidate
ampC beta-lactamase	G123D	-	-	E. coli	amoxicillin	Reslit	Candidate
ampC beta-lactamase	G157D	-	-	Pseudomonas aeruginosa	ceftolozane tazobactam	Reslit	Candidate
ampC chromosome-encoded cephalosporinase	G183D	-	decreased hydrolytic activity toward TZP and carbapenems, reduced susceptibility to inhibition by avibactam	Pseudomonas aeruginosa	ceftolozane tazobactamceftazidime avibactamceftolozane+3 more	Reslit	Supported
ampC beta-lactamase	G183R	-	-	Pseudomonas aeruginosa	ceftolozane tazobactamceftazidime avibactam	Reslit	Candidate
ampC β-lactamase	G1D	-	-	Pseudomonas aeruginosa	ceftolozane tazobactam	Reslit	Candidate
ampC AmpC β-lactamase	G214R	-	enhanced cephalosporin resistance	Pseudomonas aeruginosa	ceftazidimeceftolozane	Reslit	Candidate
ampC AmpC β-lactamase	G222S	-	enhanced cephalosporin resistance	Pseudomonas aeruginosa	ceftazidimeceftolozane	Reslit	Candidate
ampC ß-lactamase precursor	G242R	-	increased activity of the enzyme against the ceftazidime substrate	Pseudomonas aeruginosa	ceftazidime	Reslit	Candidate