Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.

PMID: 104289071999

Key Findings

These mutations were introduced into the TEM-1 beta-lactamase to study their effects on resistance to beta-lactam antibiotics and beta-lactamase inhibitors.

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0gene entries

3mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaTEM-1	G238S	-	-	E. coli	Ceftazidime\|Cefotaxime	Reslit	-
blaTEM-1	R164S	-	-	E. coli	Ceftazidime\|Cefotaxime	Reslit	-
blaTEM-1	E104K	-	-	E. coli	Ceftazidime\|Cefotaxime	Reslit	-

Browse Papers

Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.

AMR Mutations