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Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 104289351999

Key Findings

mutations in gyrA are associated with fluoroquinolone resistance

0gene entries

23mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S83Y	-	-	Klebsiella pneumoniae, Enterobacter aerogenes	Ciprofloxacin	Reslit	-
gyrA	S83F	-	-	Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes	Ciprofloxacin	Reslit	-
gyrA	D87N	-	-	Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes	Ciprofloxacin	Reslit	-
parC	S80I	-	DNA topoisomerase IV subunit A ParC	Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Klebsiella oxytoca	CiprofloxacinQUINOLONE	ReslitReference Gene Catalog	-
gyrA	S83I	-	-	Klebsiella pneumoniae, Enterobacter aerogenes	Ciprofloxacin	Reslit	-
gyrA	D87G	-	DNA gyrase subunit A GyrA	Klebsiella oxytoca, Enterobacter cloacae	CiprofloxacinQUINOLONE	ReslitReference Gene Catalog	-
parC	S80R	-	DNA topoisomerase IV subunit A ParC	Klebsiella oxytoca	CiprofloxacinQUINOLONE	ReslitReference Gene Catalog	-
gyrA	D87Y	-	-	Klebsiella pneumoniae	Ciprofloxacin	Reslit	-
gyrA	D87H	-	DNA gyrase subunit A GyrA	Enterobacter cloacae	CiprofloxacinQUINOLONE	ReslitReference Gene Catalog	-