gyrA
Overview
- Papers
- 0
- Mutations
- 446
| Nucleotide Change | Protein Change | Type | Effect on Function | Resistance To | Year | Paper | Status |
|---|---|---|---|---|---|---|---|
| - | D87N | - | - | Ciprofloxacin | 2012 | High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase. PMID: 22633335 | Not Validated |
| - | A90V | - | - | fluoroquinolones | 1999 | Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages. PMID: 10049284 | Not Validated |
| - | S83I | - | - | ciprofloxacin | 1999 | Sequence analysis of the gyrA and parC homologues of a wild-type strain of Vibrio parahaemolyticus and its fluoroquinolone-resistant mutants. PMID: 10223929 | Not Validated |
| - | S84L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| - | S84L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| - | S84L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| - | S84L | - | - | ciprofloxacin | 1999 | Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. PMID: 10390214 | Not Validated |
| - | S83Y | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | S83Y | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | D87G | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | D87H | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | S89F | - | - | fluoroquinolones | 1999 | Fluoroquinolone resistance in Bacteroides fragilis following sparfloxacin exposure. PMID: 10471574 | Not Validated |
| - | S81Y | - | - | clinafloxacin|ciprofloxacin|trovafloxacin | 2000 | In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae. PMID: 10991854 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid,Ciprofloxacin | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | Q106H | - | Target modification | Nalidixic acid,Ciprofloxacin | 1976 | Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials. PMID: 185097 | Not Validated |
| - | S83A | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | A84V | - | Target modification | Nalidixic acid,Ciprofloxacin | 2001 | Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region. PMID: 11451702 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid,Ciprofloxacin | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | Q106R | - | Target modification | Nalidixic acid,Ciprofloxacin | 1976 | Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials. PMID: 185097 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid,Ciprofloxacin | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid,Ciprofloxacin | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid,Ciprofloxacin | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid,Ciprofloxacin | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid,Ciprofloxacin | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87A | - | - | Ciprofloxacin | 2012 | High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase. PMID: 22633335 | Not Validated |
| - | D87G | - | - | Ciprofloxacin | 2012 | High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase. PMID: 22633335 | Not Validated |
| - | S83L | - | - | Ciprofloxacin | 2012 | High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase. PMID: 22633335 | Not Validated |
| - | S83F | - | - | Ciprofloxacin | 2012 | High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase. PMID: 22633335 | Not Validated |
| - | A90V | - | - | fluoroquinolones | 1999 | Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages. PMID: 10049284 | Not Validated |
| - | Y100D | - | - | norfloxacin|ciprofloxacin|sparfloxacin|ofloxacin | 2002 | Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae. PMID: 12121955 | Not Validated |
| - | S81F | - | - | levofloxacin | 2003 | Genetic relatedness of levofloxacin-nonsusceptible Streptococcus pneumoniae isolates from North America. PMID: 12791865 | Not Validated |
| - | S83I | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | D87G | - | - | ofloxacin|ciprofloxacin|trovafloxacin|sparfloxacin | 2000 | Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump. PMID: 10602715 | Not Validated |
| - | S81F | - | - | clinafloxacin|ciprofloxacin|trovafloxacin | 2000 | In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae. PMID: 10991854 | Not Validated |
| - | S84L | - | - | quinolones | 2001 | Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. PMID: 11709337 | Not Validated |
| - | S83I | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | S81L | - | - | clinafloxacin|ciprofloxacin|trovafloxacin | 2000 | In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae. PMID: 10991854 | Not Validated |
| - | D87Y | - | - | ciprofloxacin | 1999 | Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. PMID: 10428935 | Not Validated |
| - | S81F | - | - | clinafloxacin|ciprofloxacin|trovafloxacin | 2000 | In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae. PMID: 10991854 | Not Validated |
| - | T86I | - | - | fluoroquinolones | 2001 | Antimicrobial resistance and bacterial identification utilizing a microelectronic chip array. PMID: 11230433 | Not Validated |
| - | S84L | - | - | fluoroquinolones | 2002 | Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations. PMID: 11751133 | Not Validated |
| - | S83L | - | mutations in gyrA confer resistance to fluoroquinolones | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| - | D95N | - | - | ciprofloxacin | 2000 | An invasive isolate of Neisseria meningitidis showing decreased susceptibility to quinolones. PMID: 10799008 | Not Validated |
| - | S81F | - | - | levofloxacin|clinafloxacin | 2000 | Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. PMID: 11036007 | Not Validated |
| - | T83I | - | - | moxifloxacin | 2001 | Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA. PMID: 11451695 | Not Validated |
| - | S83I | - | - | norfloxacin|ciprofloxacin|sparfloxacin|ofloxacin | 2002 | Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae. PMID: 12121955 | Not Validated |
| - | S84L | - | reduced potency of ciprofloxacin | quinolones | 2001 | Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates. PMID: 11257024 | Not Validated |
| - | S82L | - | - | ciprofloxacin|levofloxacin|moxifloxacin|clinafloxacin | 2001 | gyrA Mutations Associated with Quinolone Resistance in Bacteroides fragilis Group Strains. PMID: 11408211 | Not Validated |
| - | S85P | - | - | ciprofloxacin | 2001 | Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance. PMID: 11600359 | Not Validated |
| - | E85K | - | - | levofloxacin | 2003 | Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro. PMID: 12878509 | Not Validated |
| - | S83L | - | - | ciprofloxacin|ofloxacin|nalidixic acid | 2001 | Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures. PMID: 11600360 | Not Validated |
| - | D71V | - | - | Ciprofloxacin|Moxifloxacin | 2002 | gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile. PMID: 12384345 | Not Validated |
| - | E85K | - | - | levofloxacin | 2003 | Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro. PMID: 12878509 | Not Validated |
| - | T83I | - | - | ciprofloxacin|garenoxacin | 2005 | Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime. PMID: 15917569 | Not Validated |
| - | S95T | - | - | ofloxacin | 2002 | Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India. PMID: 11796356 | Not Validated |
| - | T82I | - | - | Ciprofloxacin|Moxifloxacin | 2002 | gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile. PMID: 12384345 | Not Validated |
| - | P162T | - | - | levofloxacin | 2003 | Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro. PMID: 12878509 | Not Validated |
| - | S83L | - | - | nalidixic acid | 2001 | Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance. PMID: 11699598 | Not Validated |
| - | A118T | - | - | Ciprofloxacin|Moxifloxacin | 2002 | gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile. PMID: 12384345 | Not Validated |
| - | L83F | - | - | nalidixic acid|ciprofloxacin | 2002 | A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries. PMID: 12450802 | Not Validated |
| - | P162T | - | - | levofloxacin | 2003 | Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro. PMID: 12878509 | Not Validated |
| - | D107E | - | - | nalidixic acid | 2001 | Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance. PMID: 11699598 | Not Validated |
| - | L83F | - | - | nalidixic acid|ciprofloxacin | 2002 | A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries. PMID: 12450802 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2003 | Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans. PMID: 14718091 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2004 | Fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis, Taiwan, 2000-2003. PMID: 15498176 | Not Validated |
| - | S87V | - | - | ciprofloxacin|levofloxacin|moxifloxacin | 2005 | Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum. PMID: 15855486 | Not Validated |
| - | T83I | - | - | ciprofloxacin | 2003 | Ciprofloxacin susceptibility of Pseudomonas aeruginosa isolates from keratitis. PMID: 14507757 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2004 | Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. PMID: 15078598 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2004 | Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series. PMID: 15380025 | Not Validated |
| - | T86I | - | - | ciprofloxacin|nalidixic acid | 2005 | Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment. PMID: 15673754 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2004 | Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. PMID: 15078598 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2004 | Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series. PMID: 15380025 | Not Validated |
| - | T86I | - | - | ciprofloxacin|nalidixic acid | 2005 | Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment. PMID: 15673754 | Not Validated |
| - | D87G | - | - | ciprofloxacin | 2004 | Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. PMID: 15078598 | Not Validated |
| - | S91F | - | - | fluoroquinolones | 2004 | Use of applied biosystems 7900HT sequence detection system and Taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae. PMID: 15243093 | Not Validated |
| - | S83L | - | - | ciprofloxacin | 2005 | Isolation and molecular characterization of fluoroquinolone-resistant Escherichia coli from poultry litter. PMID: 15685943 | Not Validated |
| - | D91Y | - | - | ciprofloxacin|levofloxacin | 2005 | Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum. PMID: 15855486 | Not Validated |
| - | D83N | - | - | ciprofloxacin | 2003 | Ciprofloxacin treatment failure in typhoid fever case, Pakistan. PMID: 14720407 | Not Validated |
| - | D87G | - | - | ciprofloxacin | 2004 | Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. PMID: 15078598 | Not Validated |
| - | S83L | - | - | ciprofloxacin | 2004 | Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital. PMID: 15388428 | Not Validated |
| - | S87R | - | - | ciprofloxacin|levofloxacin|moxifloxacin | 2005 | Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum. PMID: 15855486 | Not Validated |
| - | S81Y | - | - | ciprofloxacin|garenoxacin|sparfloxacin|trovafloxacin | 2004 | Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model. PMID: 14982762 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2004 | Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. PMID: 15078598 | Not Validated |
| - | S83I | - | - | ciprofloxacin|norfloxacin | 2004 | An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients. PMID: 15567276 | Not Validated |
| - | S81Y | - | - | gemifloxacin|trovafloxacin|sparfloxacin|ciprofloxacin | 2005 | Activity of gemifloxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model. PMID: 15728901 | Not Validated |
| - | S87R | - | - | ciprofloxacin|levofloxacin|moxifloxacin | 2005 | Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum. PMID: 15855486 | Not Validated |
| - | A119E | - | - | norfloxacin | 2005 | Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections. PMID: 15917531 | Not Validated |
| - | S83L | - | - | nalidixic acid|ciprofloxacin | 2004 | Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece. PMID: 14706091 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2004 | Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. PMID: 15078598 | Not Validated |
| - | A88P | - | - | ciprofloxacin|levofloxacin|moxifloxacin | 2005 | Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum. PMID: 15855486 | Not Validated |
| - | S87F | - | - | ciprofloxacin|levofloxacin | 2005 | Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum. PMID: 15855486 | Not Validated |
| - | S81F | - | - | ciprofloxacin|levofloxacin|moxifloxacin | 2004 | Mutant prevention concentrations for single-step fluoroquinolone-resistant mutants of wild-type, efflux-positive, or ParC or GyrA mutation-containing Streptococcus pneumoniae isolates. PMID: 15388458 | Not Validated |
| - | A88P | - | - | ciprofloxacin|levofloxacin|moxifloxacin | 2005 | Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum. PMID: 15855486 | Not Validated |
| - | S91F | - | - | ciprofloxacin|gatifloxacin|levofloxacin|ofloxacin | 2005 | Cultivation of Neisseria gonorrhoeae in liquid media and determination of its in vitro susceptibilities to quinolones. PMID: 16145072 | Not Validated |
| - | S81F | - | - | fluoroquinolones | 2003 | Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae PMID: 16189113 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | S83L | - | likely ascribed to the previously characterized mutation occurring in the gyrA gene, with a substitution of Ser for Leu at position 83 of its amino acid sequence | fluoroquinolones | 2008 | Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group. PMID: 18411315 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2005 | Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan. PMID: 15963294 | Not Validated |
| - | E85K | - | - | fluoroquinolones | 2003 | Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae PMID: 16189113 | Not Validated |
| - | S83R | - | - | ciprofloxacin | 2006 | High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium. PMID: 16517894 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | S84L | - | - | enrofloxacin | 2008 | Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius. PMID: 18305127 | Not Validated |
| - | S84L | - | - | ciprofloxacin|levofloxacin|gatifloxacin | 2008 | In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. PMID: 18443108 | Not Validated |
| - | S83F | - | - | ciprofloxacin|nalidixic acid | 2006 | Fluoroquinolone-resistant Salmonella sp. in carcasses. PMID: 17080579 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | E88G | - | - | enrofloxacin | 2008 | Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius. PMID: 18305127 | Not Validated |
| - | S83F | - | - | ciprofloxacin|nalidixic acid | 2005 | Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan. PMID: 16207965 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | Q611L | - | - | enrofloxacin | 2008 | Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius. PMID: 18305127 | Not Validated |
| - | S81I | - | - | ciprofloxacin|levofloxacin|moxifloxacin|gatifloxacin|gemifloxacin|garenoxacin|norfloxacin | 2005 | Novel Ser79Leu and Ser81Ile Substitutions in the Quinolone Resistance-Determining Regions of ParC Topoisomerase IV and GyrA DNA Gyrase Subunits from Recent Fluoroquinolone-Resistant Streptococcus pneumoniae Clinical Isolates. PMID: 15917550 | Not Validated |
| - | S83L | - | - | ciprofloxacin | 2006 | Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase. PMID: 16451415 | Not Validated |
| - | S83F | - | - | levofloxacin | 2007 | Impact of resistance selection and mutant growth fitness on the relative efficacies of streptomycin and levofloxacin for plague therapy. PMID: 17517837 | Not Validated |
| - | Y83C | - | - | ofloxacin | 2008 | Interstrain gene transfer in Chlamydia trachomatis in vitro: mechanism and significance. PMID: 18083799 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2005 | Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan. PMID: 15963294 | Not Validated |
| - | S81Y | - | - | fluoroquinolones | 2003 | Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae PMID: 16189113 | Not Validated |
| - | D87G | - | - | ciprofloxacin | 2007 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. PMID: 17043131 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | D87N | - | - | ciprofloxacin|nalidixic acid | 2005 | Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan. PMID: 16207965 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2006 | Clonal emergence of extended-spectrum beta-lactamase (CTX-M-2)-producing Salmonella enterica serovar Virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in Belgium and France (2000 to 2003). PMID: 16891509 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | E714K | - | - | enrofloxacin | 2008 | Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius. PMID: 18305127 | Not Validated |
| - | D87G | - | - | ciprofloxacin|nalidixic acid | 2005 | Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan. PMID: 16207965 | Not Validated |
| - | D87Y | - | - | nalidixic acid | 2006 | Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms. PMID: 16416922 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2007 | International spread of multidrug-resistant Salmonella Schwarzengrund in food products. PMID: 17553251 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | T678A | - | - | enrofloxacin | 2008 | Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius. PMID: 18305127 | Not Validated |
| - | D87N | - | - | nalidixic acid | 2006 | Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms. PMID: 16416922 | Not Validated |
| - | T83I | - | - | fluoroquinolones | 2007 | Outbreaks of multidrug-resistant Pseudomonas aeruginosa in community hospitals in Japan. PMID: 17122009 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | D87Y | - | - | nalidixic acid|ciprofloxacin | 2007 | Quinolone Resistance of Salmonella enterica Serovar Virchow Isolates from Humans and Poultry in Israel: Evidence for Clonal Expansion. PMID: 17596371 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | T83I | - | - | fluoroquinolones | 2006 | Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase. PMID: 16451415 | Not Validated |
| - | S83L | - | - | ciprofloxacin | 2006 | Ciprofloxacin-resistant gram-negative bacilli in the fecal microflora of children. PMID: 17005812 | Not Validated |
| - | S91T | - | - | ciprofloxacin | 2006 | Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae. PMID: 17207083 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2007 | Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. PMID: 18217551 | Not Validated |
| - | T82I | - | - | moxifloxacin|ciprofloxacin|gatifloxacin|levofloxacin | 2008 | Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe. PMID: 18480338 | Not Validated |
| - | S83L | - | - | ciprofloxacin | 2008 | Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America. PMID: 18648533 | Not Validated |
| - | D87E | - | - | nalidixic acid | 2008 | Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5 PMID: 18708504 | Not Validated |
| - | S83L | - | - | quinolones | 2008 | Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5 PMID: 18708504 | Not Validated |
| - | S83A | - | - | ciprofloxacin | 1991 | Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins. PMID: 1850970 | Not Validated |
| - | Q106R | - | - | ciprofloxacin | 1991 | Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins. PMID: 1850970 | Not Validated |
| - | T82I | - | confers resistance | ciprofloxacin|moxifloxacin|levofloxacin | 2009 | Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model. PMID: 18710908 | Not Validated |
| - | S83L | - | - | ciprofloxacin | 2008 | Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California. PMID: 18524965 | Not Validated |
| - | D87Y | - | confers resistance | ciprofloxacin | 2009 | Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of ramA and other global regulators. PMID: 19104017 | Not Validated |
| - | T82I | - | - | moxifloxacin|levofloxacin | 2009 | Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro. PMID: 19364867 | Not Validated |
| - | S83L | - | - | fluoroquinolones | 2009 | A novel mechanism of transposon-mediated gene activation. PMID: 19834539 | Not Validated |
| - | A147G | - | - | moxifloxacin|levofloxacin|gemifloxacin | 2010 | Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. PMID: 20008781 | Not Validated |
| - | S83L | - | - | ciprofloxacin | 2008 | Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania. PMID: 18725452 | Not Validated |
| - | S81A | - | - | moxifloxacin|levofloxacin|gemifloxacin | 2010 | Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. PMID: 20008781 | Not Validated |
| - | S83L | - | - | ciprofloxacin|levofloxacin | 2008 | Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. PMID: 18591275 | Not Validated |
| - | S83I | - | - | nalidixic acid|oxolinic acid|fluoroquinolones | 2009 | Spontaneous quinolone resistance in the zoonotic serovar of Vibrio vulnificus. PMID: 19218407 | Not Validated |
| - | S81F | - | - | moxifloxacin|levofloxacin|gemifloxacin | 2010 | Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. PMID: 20008781 | Not Validated |
| - | S83L | - | - | nalidixic acid | 2008 | Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5 PMID: 18708504 | Not Validated |
| - | S83L | - | - | fluoroquinolones | 2010 | Molecular Diagnostic Technologies in Clinical Microbiology PMID: 19377839 | Not Validated |
| - | S81Y | - | - | moxifloxacin|levofloxacin|gemifloxacin | 2010 | Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. PMID: 20008781 | Not Validated |
| - | D87N | - | - | ciprofloxacin | 2009 | Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR. PMID: 19205458 | Not Validated |
| - | S84L | - | - | ciprofloxacin|levofloxacin | 2010 | Skin lesion caused by ST398 and ST1 MRSA, Spain. PMID: 20031071 | Not Validated |
| - | S81F | - | - | fluoroquinolones | 2010 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. PMID: 20176911 | Not Validated |
| - | S84L | - | - | fluoroquinolones | 2010 | Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae. PMID: 20435780 | Not Validated |
| - | T86K | - | Target modification | Nalidixic acid, Ciprofloxacin | - | Not Validated | |
| - | E85K | - | - | moxifloxacin|levofloxacin|gemifloxacin | 2010 | Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. PMID: 20008781 | Not Validated |
| - | S83F | - | - | ciprofloxacin | 2009 | Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR. PMID: 19205458 | Not Validated |
| - | E85A | - | - | moxifloxacin|levofloxacin|gemifloxacin | 2010 | Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. PMID: 20008781 | Not Validated |
| - | S83Y | - | - | ciprofloxacin | 2010 | Fluoroquinolone-resistant typhoid, South Africa. PMID: 20409393 | Not Validated |
| - | D87G | - | - | ciprofloxacin | 2009 | Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR. PMID: 19205458 | Not Validated |
| - | T83I | - | - | fluoroquinolones | 2009 | Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa. PMID: 19656662 | Not Validated |
| - | A90V | - | - | fluoroquinolones | 2009 | Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. PMID: 19890396 | Not Validated |
| - | S82P | - | - | moxifloxacin|levofloxacin|gemifloxacin | 2010 | Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. PMID: 20008781 | Not Validated |
| - | S81F | - | - | fluoroquinolones | 2010 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. PMID: 20176911 | Not Validated |
| - | S84L | - | - | fluoroquinolones | 2010 | Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae. PMID: 20435780 | Not Validated |
| - | N87I | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | S84L | - | - | fluoroquinolones | 2010 | Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae. PMID: 20435780 | Not Validated |
| - | D91N | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | D94G | - | - | ofloxacin | 2010 | Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis. PMID: 20573868 | Not Validated |
| - | R128S | - | - | fluoroquinolones | 2010 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. PMID: 20713679 | Not Validated |
| - | S83F | - | - | nalidixic acid|ciprofloxacin | 2010 | Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007. PMID: 20113512 | Not Validated |
| - | S84L | - | - | fluoroquinolones | 2010 | Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae. PMID: 20435780 | Not Validated |
| - | D91G | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | D94N | - | - | ofloxacin | 2010 | Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis. PMID: 20573868 | Not Validated |
| - | Y129C | - | - | fluoroquinolones | 2010 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. PMID: 20713679 | Not Validated |
| - | S83F | - | - | nalidixic acid|ciprofloxacin | 2010 | Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007. PMID: 20113512 | Not Validated |
| - | D91Y | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | A90V | - | - | ofloxacin | 2010 | Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis. PMID: 20573868 | Not Validated |
| - | S83L | - | - | ciprofloxacin|ofloxacin | 2010 | Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi. PMID: 20138477 | Not Validated |
| - | R140K | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | S83L | - | - | levofloxacin | 2010 | The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients. PMID: 20597679 | Not Validated |
| - | G82D | - | - | norfloxacin | 2010 | Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis. PMID: 20159551 | Not Validated |
| - | V150A | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | T82I | - | - | moxifloxacin|ciprofloxacin|levofloxacin|gatifloxacin | 2010 | Clostridium difficile Isolates Resistant to Fluoroquinolones in Italy: Emergence of PCR Ribotype 018 PMID: 20554809 | Not Validated |
| - | D87E | - | - | levofloxacin | 2010 | The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients. PMID: 20597679 | Not Validated |
| - | V150A | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | N87K | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | S83Y | - | reduced susceptibility to ciprofloxacin | ciprofloxacin | 2010 | In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B. PMID: 20566759 | Not Validated |
| - | S83L | - | - | levofloxacin | 2010 | Impact of recA on levofloxacin exposure-related resistance development. PMID: 20660686 | Not Validated |
| - | D94G | - | - | fluoroquinolones | 2010 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. PMID: 20713679 | Not Validated |
| - | N87Y | - | - | levofloxacin|moxifloxacin|ciprofloxacin | 2010 | Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains. PMID: 20458765 | Not Validated |
| - | A90V | - | - | fluoroquinolones | 2010 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. PMID: 20713679 | Not Validated |
| - | S83Y | - | reduced susceptibility to ciprofloxacin | ciprofloxacin | 2010 | In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B. PMID: 20566759 | Not Validated |
| - | S83L | - | - | levofloxacin | 2010 | Impact of recA on levofloxacin exposure-related resistance development. PMID: 20660686 | Not Validated |
| - | S95T | - | - | fluoroquinolones | 2010 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. PMID: 20713679 | Not Validated |
| - | D94N | - | - | fluoroquinolones | 2010 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. PMID: 20713679 | Not Validated |
| - | A70T | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D85Y | - | Target modification | Nalidixic acid, Ciprofloxacin | 2007 | Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli. PMID: 18031331 | Not Validated |
| - | T86I | - | Target modification | Nalidixic acid, Ciprofloxacin | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| - | T86I | - | Target modification | Nalidixic acid, Ciprofloxacin | - | Not Validated | |
| - | T86I | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | T86I | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | T86A | - | Target modification | Nalidixic acid, Ciprofloxacin | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| - | T86A | - | Target modification | Nalidixic acid, Ciprofloxacin | - | Not Validated | |
| - | T86A | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | T86A | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | T86K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| - | T86V | - | Target modification | Nalidixic acid, Ciprofloxacin | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| - | T86V | - | Target modification | Nalidixic acid, Ciprofloxacin | - | Not Validated | |
| - | D90N | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | T86I | - | Target modification | Nalidixic acid, Ciprofloxacin | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| - | T86A | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | T86V | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | S83R | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83N | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87L | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83I | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | T86K | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | T86K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | T86V | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D90A | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | D90N | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | D90T | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D85Y | - | Target modification | Nalidixic acid, Ciprofloxacin | 2007 | Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli. PMID: 18031331 | Not Validated |
| - | T86A | - | Target modification | Nalidixic acid, Ciprofloxacin | - | Not Validated | |
| - | T86A | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | T86K | - | Target modification | Nalidixic acid, Ciprofloxacin | - | Not Validated | |
| - | T86V | - | Target modification | Nalidixic acid, Ciprofloxacin | - | Not Validated | |
| - | T86V | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | D90N | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | S83I | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83Y | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | T86V | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | T86I | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | T86K | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D90T | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | S83L | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | E87K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87L | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | G81C | - | Target modification | Nalidixic acid,Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | S83L | - | Target modification | Nalidixic acid,Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | D90A | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D90A | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D90T | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D90T | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | A70T | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | T86A | - | Target modification | Nalidixic acid, Ciprofloxacin | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| - | T86K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | D90A | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D90T | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | S83N | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | S83Y | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | E87G | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83N | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83N | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | D90N | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | T86K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| - | D90A | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D90N | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | S83L | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S97N | - | Target modification | Nalidixic acid, Ciprofloxacin | 1999 | Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones. PMID: 10508034 | Not Validated |
| - | S83R | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83L | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83L | - | Target modification | Nalidixic acid,Ciprofloxacin | 1996 | Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. PMID: 8891148 | Not Validated |
| - | S83V | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | P104S | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | T86I | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | D90A | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | D90T | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | S83R | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | S83Y | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87G | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | G81D | - | Target modification | Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | D82G | - | Target modification | Nalidixic acid,Ciprofloxacin | 1997 | A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics. PMID: 8980760 | Not Validated |
| - | S83W | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | S83V | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | T86I | - | Target modification | Nalidixic acid, Ciprofloxacin | - | Not Validated | |
| - | T86V | - | Target modification | Nalidixic acid, Ciprofloxacin | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| - | D90N | - | Target modification | Nalidixic acid, Ciprofloxacin | 1993 | Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. PMID: 8384814 | Not Validated |
| - | P104S | - | Target modification | Nalidixic acid, Ciprofloxacin | 2006 | Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. PMID: 16713726 | Not Validated |
| - | S83R | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | S83I | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | E87G | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87L | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | G81C | - | Target modification | Nalidixic acid,Ciprofloxacin | 1993 | Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid. PMID: 8392306 | Not Validated |
| - | S83L | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | E87K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87L | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83I | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83Y | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | G81C | - | Target modification | Ciprofloxacin | 1993 | Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid. PMID: 8392306 | Not Validated |
| - | S83W | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | E87G | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S83L | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | S83A | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid,Ciprofloxacin | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | Q106R | - | Target modification | Nalidixic acid,Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | S83L | - | Target modification | Nalidixic acid, Ciprofloxacin | 1998 | Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. PMID: 9527801 | Not Validated |
| - | E87G | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87L | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | A67S | - | Target modification | Nalidixic acid | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | G81D | - | Target modification | Nalidixic acid,Ciprofloxacin | 1993 | Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid. PMID: 8392306 | Not Validated |
| - | S83W | - | Target modification | Nalidixic acid,Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | S83V | - | Target modification | Nalidixic acid,Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | E87K | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | E87L | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | G81C | - | Target modification | Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | D82G | - | Target modification | Ciprofloxacin | 1997 | A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics. PMID: 8980760 | Not Validated |
| - | S83V | - | Target modification | Nalidixic acid,Ciprofloxacin | 1996 | Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. PMID: 8891148 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid,Ciprofloxacin | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid,Ciprofloxacin | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | A196E | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| - | E87G | - | Target modification | Nalidixic acid, Ciprofloxacin | 2002 | Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. PMID: 12373497 | Not Validated |
| - | S97N | - | Target modification | Nalidixic acid, Ciprofloxacin | 1999 | Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones. PMID: 10508034 | Not Validated |
| - | G81D | - | Target modification | Ciprofloxacin | 1993 | Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid. PMID: 8392306 | Not Validated |
| - | S83A | - | Target modification | Nalidixic acid,Ciprofloxacin | 1996 | Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. PMID: 8891148 | Not Validated |
| - | A84P | - | Target modification | Nalidixic acid,Ciprofloxacin | 2001 | Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region. PMID: 11451702 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid | 1991 | 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. PMID: 1850972 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid,Ciprofloxacin | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | Q106H | - | Target modification | Nalidixic acid,Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | A51V | - | Target modification | Nalidixic acid | 2001 | Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region. PMID: 11451702 | Not Validated |
| - | G81D | - | Target modification | Nalidixic acid,Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | S83W | - | Target modification | Nalidixic acid,Ciprofloxacin | 1996 | Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. PMID: 8891148 | Not Validated |
| - | A84V | - | Target modification | Nalidixic acid,Ciprofloxacin | 1994 | Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs. PMID: 7840592 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87A | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87N | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87G | - | Target modification | Nalidixic acid,Ciprofloxacin | 2012 | Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals. PMID: 22878251 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87H | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | D87V | - | Target modification | Nalidixic acid,Ciprofloxacin | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| - | S83A | - | Target modification | Nalidixic acid,Ciprofloxacin | 1990 | Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. PMID: 2168148 | Not Validated |
| - | A84P | - | Target modification | Nalidixic acid,Ciprofloxacin | 1994 | Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs. PMID: 7840592 | Not Validated |
| - | D87Y | - | Target modification | Nalidixic acid | 2003 | Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. PMID: 12654733 | Not Validated |
| A258C | - | - | - | fluoroquinolones | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| A259G | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| A259G | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| A259G | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| A259G | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| A261G | - | - | - | ciprofloxacin | 2004 | Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece. PMID: 14706091 | Not Validated |
| A271T | - | - | - | fluoroquinolones | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| AGT -> TTC | S81F | - | - | fluoroquinolones | 2008 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. PMID: 17938189 | Not Validated |
| AGT->GAA | - | - | - | ciprofloxacin|nalidixic acid | 2010 | A predominant multidrug-resistant Salmonella enterica serovar Saintpaul clonal line in German turkey and related food products. PMID: 20363784 | Not Validated |
| C257T | S86L | - | - | quinolone | 2009 | Multiplex strategy for multilocus sequence typing, fla typing, and genetic determination of antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates collected in Switzerland. PMID: 19439549 | Not Validated |
| C257T | S86L | - | - | quinolone | 2009 | Multiplex strategy for multilocus sequence typing, fla typing, and genetic determination of antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates collected in Switzerland. PMID: 19439549 | Not Validated |
| G210A | - | - | - | fluoroquinolones | 2001 | Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. PMID: 11266291 | Not Validated |
| G244C | - | - | - | ciprofloxacin | 2004 | Dynamics of Long-Term Colonization of Respiratory Tract by Haemophilus influenzae in Cystic Fibrosis Patients Shows a Marked Increase in Hypermutable Strains. PMID: 15070988 | Not Validated |
| G247A | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G247A | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G247C | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G247C | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G248A | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G248A | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G248T | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G248T | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G249A | S83L | - | - | nalidixic acid|ciprofloxacin | 2004 | Emerging nalidixic acid and ciprofloxacin resistance in non-typhoidal Salmonella isolated from patients having acute diarrhoeal disease. PMID: 15387492 | Not Validated |
| G249T | - | - | - | fluoroquinolones | 2008 | Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States FoodNet multicenter retrospective cohort study. PMID: 18212096 | Not Validated |
| G259A | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G259A | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G260A | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G260A | - | - | - | fluoroquinolones | 2010 | A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A. PMID: 20511368 | Not Validated |
| G262T | D88Y | - | - | ciprofloxacin | 2005 | Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency. PMID: 15980348 | Not Validated |
| G281A | D94N | - | - | fluoroquinolones | 2007 | In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis. PMID: 17938193 | Not Validated |
| G81A | - | - | - | ciprofloxacin | 2001 | Detection of Ciprofloxacin-Resistant Yersinia pestis by Fluorogenic PCR Using the LightCycler. PMID: 11574586 | Not Validated |
| GAT->AAT | D87N | - | - | quinolones | 2004 | Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates. PMID: 15364994 | Not Validated |
| GAT->GGT | D87G | - | - | quinolones | 2004 | Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates. PMID: 15364994 | Not Validated |
| GAT->TAT | D87Y | - | - | quinolones | 2004 | Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates. PMID: 15364994 | Not Validated |
| T1560A | - | - | - | ciprofloxacin|levofloxacin|gatifloxacin | 2008 | In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. PMID: 18443108 | Not Validated |
| T248A | - | - | - | ciprofloxacin|norfloxacin | 2009 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. PMID: 18838592 | Not Validated |
| T260A | - | - | - | ciprofloxacin|norfloxacin | 2009 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. PMID: 18838592 | Not Validated |
| T84C | L84S | - | - | ciprofloxacin | 2007 | Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus. PMID: 17986343 | Not Validated |
| TCA->CTA | S83L | - | - | quinolones | 2004 | Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates. PMID: 15364994 | Not Validated |
| TCC->CTC | - | - | - | ciprofloxacin | 2004 | Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece. PMID: 14706091 | Not Validated |
High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.
PMID 22633335 · 2012Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages.
PMID 10049284 · 1999Mutation in gyrA at position 90 (A90V) confers resistance to fluoroquinolones.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A90V
Confers Resistance To
Organisms Observed In
Sequence analysis of the gyrA and parC homologues of a wild-type strain of Vibrio parahaemolyticus and its fluoroquinolone-resistant mutants.
PMID 10223929 · 1999Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutation in gyrA codon 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutation in gyrA codon 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutation in gyrA codon 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
PMID 10390214 · 1999Mutation in gyrA codon 84 associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Fluoroquinolone resistance in Bacteroides fragilis following sparfloxacin exposure.
PMID 10471574 · 1999A mutation in the quinolone resistance-determining region (QRDR) of gyrA was identified as the mechanism of fluoroquinolone resistance in B. fragilis.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S89F
Confers Resistance To
Organisms Observed In
In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.
PMID 10991854 · 2000Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81Y
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials.
PMID 185097 · 1976Unknown phenotype if Q106H occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- Q106H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.
PMID 11451702 · 2001Unknown phenotype if A84P or A84V occur alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A84V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials.
PMID 185097 · 1976Unknown phenotype if Q106H occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- Q106R
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.
PMID 22633335 · 2012Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Confers Resistance To
Organisms Observed In
High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.
PMID 22633335 · 2012Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.
PMID 22633335 · 2012Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.
PMID 22633335 · 2012Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages.
PMID 10049284 · 1999Mutation in gyrA at position 90 (A90V) confers resistance to fluoroquinolones.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A90V
Confers Resistance To
Organisms Observed In
Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.
PMID 12121955 · 2002Mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- Y100D
Confers Resistance To
Organisms Observed In
Genetic relatedness of levofloxacin-nonsusceptible Streptococcus pneumoniae isolates from North America.
PMID 12791865 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Confers Resistance To
Organisms Observed In
Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump.
PMID 10602715 · 2000Mutation in gyrA contributes to fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.
PMID 10991854 · 2000Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.
PMID 11709337 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Confers Resistance To
Organisms Observed In
In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.
PMID 10991854 · 2000Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81L
Confers Resistance To
Organisms Observed In
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
PMID 10428935 · 1999mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Confers Resistance To
Organisms Observed In
In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.
PMID 10991854 · 2000Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Antimicrobial resistance and bacterial identification utilizing a microelectronic chip array.
PMID 11230433 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Confers Resistance To
Organisms Observed In
Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.
PMID 11751133 · 2002Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
mutations in gyrA confer resistance to fluoroquinolones
Confers Resistance To
Organisms Observed In
An invasive isolate of Neisseria meningitidis showing decreased susceptibility to quinolones.
PMID 10799008 · 2000Mutation in the quinolone resistance determining region (QRDR) of the gyrA gene
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D95N
Confers Resistance To
Organisms Observed In
Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae.
PMID 11036007 · 2000Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA.
PMID 11451695 · 2001Thirteen isolates showed the same nucleotide transition (ACT→ATT) resulting in a threonine→isoleucine change. In one isolate (1542), two nucleotide changes (ACT→GTT) resulted in a replacement of threonine by valine.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T83I
Confers Resistance To
Organisms Observed In
Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.
PMID 12121955 · 2002Mutations in gyrA are associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Confers Resistance To
Organisms Observed In
Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.
PMID 11257024 · 2001Mutations promoted from gene entry 'gyrA' (model emitted mutations_found inside genes).
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Effect on Function
reduced potency of ciprofloxacin
Confers Resistance To
Organisms Observed In
gyrA Mutations Associated with Quinolone Resistance in Bacteroides fragilis Group Strains.
PMID 11408211 · 2001Mutations at position 82 (Ser82Leu) were associated with high-level resistance to all quinolones tested.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S82L
Confers Resistance To
Organisms Observed In
Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance.
PMID 11600359 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- S85P
Confers Resistance To
Organisms Observed In
Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.
PMID 12878509 · 2003Mutations in gyrA contribute to levofloxacin resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E85K
Confers Resistance To
Organisms Observed In
Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures.
PMID 11600360 · 2001Single point mutations in gyrA are associated with reduced susceptibility to fluoroquinolones.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.
PMID 12384345 · 2002Mutation Information
- Gene Name
- gyrA
- Protein Change
- D71V
Confers Resistance To
Organisms Observed In
Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.
PMID 12878509 · 2003Mutations in gyrA contribute to levofloxacin resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E85K
Confers Resistance To
Organisms Observed In
Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime.
PMID 15917569 · 2005Mutation Information
- Gene Name
- gyrA
- Protein Change
- T83I
Confers Resistance To
Organisms Observed In
Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.
PMID 11796356 · 2002Mutation Information
- Gene Name
- gyrA
- Protein Change
- S95T
Confers Resistance To
Organisms Observed In
gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.
PMID 12384345 · 2002Mutation Information
- Gene Name
- gyrA
- Protein Change
- T82I
Confers Resistance To
Organisms Observed In
Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.
PMID 12878509 · 2003Mutations in gyrA contribute to levofloxacin resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- P162T
Confers Resistance To
Organisms Observed In
Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance.
PMID 11699598 · 2001Mutations in gyrA alone or in combination with parC were linked to nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.
PMID 12384345 · 2002Mutation Information
- Gene Name
- gyrA
- Protein Change
- A118T
Confers Resistance To
Organisms Observed In
A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.
PMID 12450802 · 2002Mutation in the quinolone resistance-determining region
Mutation Information
- Gene Name
- gyrA
- Protein Change
- L83F
Confers Resistance To
Organisms Observed In
Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.
PMID 12878509 · 2003Mutations in gyrA contribute to levofloxacin resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- P162T
Confers Resistance To
Organisms Observed In
Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance.
PMID 11699598 · 2001Mutations in gyrA alone or in combination with parC were linked to nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D107E
Confers Resistance To
Organisms Observed In
A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.
PMID 12450802 · 2002Mutation in the quinolone resistance-determining region
Mutation Information
- Gene Name
- gyrA
- Protein Change
- L83F
Confers Resistance To
Organisms Observed In
Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans.
PMID 14718091 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis, Taiwan, 2000-2003.
PMID 15498176 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.
PMID 15855486 · 2005mutations in the QRDR of the gyrA gene are associated with quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S87V
Confers Resistance To
Organisms Observed In
Ciprofloxacin susceptibility of Pseudomonas aeruginosa isolates from keratitis.
PMID 14507757 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- T83I
Confers Resistance To
Organisms Observed In
Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.
PMID 15078598 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series.
PMID 15380025 · 2004Five isolates had this mutation.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment.
PMID 15673754 · 2005The Thr-86→Ile mutation in gyrA was the most common mutation associated with ciprofloxacin and nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Confers Resistance To
Organisms Observed In
Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.
PMID 15078598 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series.
PMID 15380025 · 2004Five isolates had this mutation.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment.
PMID 15673754 · 2005The Thr-86→Ile mutation in gyrA was the most common mutation associated with ciprofloxacin and nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Confers Resistance To
Organisms Observed In
Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.
PMID 15078598 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
Use of applied biosystems 7900HT sequence detection system and Taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae.
PMID 15243093 · 2004associated with ciprofloxacin resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91F
Confers Resistance To
Organisms Observed In
Isolation and molecular characterization of fluoroquinolone-resistant Escherichia coli from poultry litter.
PMID 15685943 · 2005Single mutation at Ser83Leu or Asp87Asn associated with low-level resistance; double mutations at Ser83Leu and Asp87Asn associated with high-level resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.
PMID 15855486 · 2005mutations in the QRDR of the gyrA gene are associated with quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D91Y
Confers Resistance To
Organisms Observed In
Ciprofloxacin treatment failure in typhoid fever case, Pakistan.
PMID 14720407 · 2003Single point mutation in the quinolone-resistance-determining region (QRDR) of the topoisomerase gene gyrA
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D83N
Confers Resistance To
Organisms Observed In
Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.
PMID 15078598 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital.
PMID 15388428 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.
PMID 15855486 · 2005mutations in the QRDR of the gyrA gene are associated with quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S87R
Confers Resistance To
Organisms Observed In
Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.
PMID 14982762 · 2004Mutation in gyrA leads to quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81Y
Confers Resistance To
Organisms Observed In
Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.
PMID 15078598 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients.
PMID 15567276 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Confers Resistance To
Organisms Observed In
Activity of gemifloxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.
PMID 15728901 · 2005Mutations in gyrA were associated with increased resistance to fluoroquinolones.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81Y
Confers Resistance To
Organisms Observed In
Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.
PMID 15855486 · 2005mutations in the QRDR of the gyrA gene are associated with quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S87R
Confers Resistance To
Organisms Observed In
Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.
PMID 15917531 · 2005Mutation Information
- Gene Name
- gyrA
- Protein Change
- A119E
Confers Resistance To
Organisms Observed In
Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.
PMID 14706091 · 2004Most frequent mutation
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.
PMID 15078598 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.
PMID 15855486 · 2005mutations in the QRDR of the gyrA gene are associated with quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A88P
Confers Resistance To
Organisms Observed In
Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.
PMID 15855486 · 2005mutations in the QRDR of the gyrA gene are associated with quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S87F
Confers Resistance To
Organisms Observed In
Mutant prevention concentrations for single-step fluoroquinolone-resistant mutants of wild-type, efflux-positive, or ParC or GyrA mutation-containing Streptococcus pneumoniae isolates.
PMID 15388458 · 2004Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.
PMID 15855486 · 2005mutations in the QRDR of the gyrA gene are associated with quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A88P
Confers Resistance To
Organisms Observed In
Cultivation of Neisseria gonorrhoeae in liquid media and determination of its in vitro susceptibilities to quinolones.
PMID 16145072 · 2005Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91F
Confers Resistance To
Organisms Observed In
Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae
PMID 16189113 · 2003Mutations in gyrA are associated with fluoroquinolone resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.
PMID 18411315 · 2008Mutation in gyrA leads to fluoroquinolone resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
likely ascribed to the previously characterized mutation occurring in the gyrA gene, with a substitution of Ser for Leu at position 83 of its amino acid sequence
Confers Resistance To
Organisms Observed In
Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan.
PMID 15963294 · 2005Mutations in gyrA and parC contribute to ciprofloxacin resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae
PMID 16189113 · 2003Mutations in gyrA are associated with fluoroquinolone resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E85K
Confers Resistance To
Organisms Observed In
High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium.
PMID 16517894 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83R
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
PMID 18305127 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.
PMID 18443108 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Fluoroquinolone-resistant Salmonella sp. in carcasses.
PMID 17080579 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
PMID 18305127 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- E88G
Confers Resistance To
Organisms Observed In
Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.
PMID 16207965 · 2005Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
PMID 18305127 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- Q611L
Confers Resistance To
Organisms Observed In
Novel Ser79Leu and Ser81Ile Substitutions in the Quinolone Resistance-Determining Regions of ParC Topoisomerase IV and GyrA DNA Gyrase Subunits from Recent Fluoroquinolone-Resistant Streptococcus pneumoniae Clinical Isolates.
PMID 15917550 · 2005Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81I
Confers Resistance To
Organisms Observed In
Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase.
PMID 16451415 · 2006mutations in the quinolone resistance-determining regions of gyrA and parC
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Impact of resistance selection and mutant growth fitness on the relative efficacies of streptomycin and levofloxacin for plague therapy.
PMID 17517837 · 2007Mutations in gyrA were associated with reduced susceptibility to levofloxacin.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Interstrain gene transfer in Chlamydia trachomatis in vitro: mechanism and significance.
PMID 18083799 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- Y83C
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan.
PMID 15963294 · 2005Mutations in gyrA and parC contribute to ciprofloxacin resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae
PMID 16189113 · 2003Mutations in gyrA are associated with fluoroquinolone resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81Y
Confers Resistance To
Organisms Observed In
Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
PMID 17043131 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.
PMID 16207965 · 2005Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Clonal emergence of extended-spectrum beta-lactamase (CTX-M-2)-producing Salmonella enterica serovar Virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in Belgium and France (2000 to 2003).
PMID 16891509 · 2006Single mutation in gyrA gene associated with reduced ciprofloxacin susceptibility.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
PMID 18305127 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- E714K
Confers Resistance To
Organisms Observed In
Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.
PMID 16207965 · 2005Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms.
PMID 16416922 · 2006Mutations in the quinolone resistance-determining region of gyrA contribute to nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
International spread of multidrug-resistant Salmonella Schwarzengrund in food products.
PMID 17553251 · 2007Single base substitution in gyrA gene at codon 83 (Ser→Phe) and 87 (Asp→Asn)
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
PMID 18305127 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- T678A
Confers Resistance To
Organisms Observed In
Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms.
PMID 16416922 · 2006Mutations in the quinolone resistance-determining region of gyrA contribute to nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Outbreaks of multidrug-resistant Pseudomonas aeruginosa in community hospitals in Japan.
PMID 17122009 · 2007associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T83I
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
Quinolone Resistance of Salmonella enterica Serovar Virchow Isolates from Humans and Poultry in Israel: Evidence for Clonal Expansion.
PMID 17596371 · 2007The Asp87Tyr substitution was observed in all resistant isolates.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase.
PMID 16451415 · 2006mutations in the quinolone resistance-determining regions of gyrA and parC
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T83I
Confers Resistance To
Organisms Observed In
Ciprofloxacin-resistant gram-negative bacilli in the fecal microflora of children.
PMID 17005812 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.
PMID 17207083 · 2006Wild-type gyrA sequence is susceptible to ciprofloxacin
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S91T
Confers Resistance To
Organisms Observed In
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
PMID 18217551 · 2007Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe.
PMID 18480338 · 2008Thr82Ile was the most frequent amino acid change identified
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T82I
Confers Resistance To
Organisms Observed In
Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.
PMID 18648533 · 2008Mutations in gyrA and parC were associated with fluoroquinolone resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5
PMID 18708504 · 2008Single amino acid substitutions in GyrA are sufficient for high-level nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87E
Confers Resistance To
Organisms Observed In
Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5
PMID 18708504 · 2008Single amino acid substitutions in GyrA are sufficient for high-level nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.
PMID 1850970 · 1991Mutant enzymes required 10 times more drug to inhibit reaction
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83A
Confers Resistance To
Organisms Observed In
Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.
PMID 1850970 · 1991Mutant enzymes required 10 times more drug to inhibit reaction
Mutation Information
- Gene Name
- gyrA
- Protein Change
- Q106R
Confers Resistance To
Organisms Observed In
Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model.
PMID 18710908 · 2009Mutation present in both parent strains and resistant mutants.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T82I
Effect on Function
confers resistance
Confers Resistance To
Organisms Observed In
Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California.
PMID 18524965 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of ramA and other global regulators.
PMID 19104017 · 2009Single mutation in all high-level nalidixic acid-resistant strains.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
confers resistance
Confers Resistance To
Organisms Observed In
Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.
PMID 19364867 · 2009Mutation Information
- Gene Name
- gyrA
- Protein Change
- T82I
Confers Resistance To
Organisms Observed In
A novel mechanism of transposon-mediated gene activation.
PMID 19834539 · 2009Mutation in gyrA was shown to contribute to fluoroquinolone resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
PMID 20008781 · 2010mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A147G
Confers Resistance To
Organisms Observed In
Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania.
PMID 18725452 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
PMID 20008781 · 2010mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81A
Confers Resistance To
Organisms Observed In
Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City.
PMID 18591275 · 2008Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Spontaneous quinolone resistance in the zoonotic serovar of Vibrio vulnificus.
PMID 19218407 · 2009Mutation in gyrA leads to quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Confers Resistance To
Organisms Observed In
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
PMID 20008781 · 2010mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5
PMID 18708504 · 2008Single amino acid substitutions in GyrA are sufficient for high-level nalidixic acid resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Molecular Diagnostic Technologies in Clinical Microbiology
PMID 19377839 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
PMID 20008781 · 2010mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81Y
Confers Resistance To
Organisms Observed In
Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.
PMID 19205458 · 2009Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Skin lesion caused by ST398 and ST1 MRSA, Spain.
PMID 20031071 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.
PMID 20176911 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.
PMID 20435780 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
PMID 20008781 · 2010mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E85K
Confers Resistance To
Organisms Observed In
Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.
PMID 19205458 · 2009Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
PMID 20008781 · 2010mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E85A
Confers Resistance To
Organisms Observed In
Fluoroquinolone-resistant typhoid, South Africa.
PMID 20409393 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Confers Resistance To
Organisms Observed In
Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.
PMID 19205458 · 2009Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa.
PMID 19656662 · 2009Mutations in codons 83 and 87 of gyrA are associated with fluoroquinolone resistance.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T83I
Confers Resistance To
Organisms Observed In
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.
PMID 19890396 · 2009Mutation Information
- Gene Name
- gyrA
- Protein Change
- A90V
Confers Resistance To
Organisms Observed In
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
PMID 20008781 · 2010mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S82P
Confers Resistance To
Organisms Observed In
In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.
PMID 20176911 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.
PMID 20435780 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- N87I
Confers Resistance To
Organisms Observed In
Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.
PMID 20435780 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D91N
Confers Resistance To
Organisms Observed In
Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.
PMID 20573868 · 2010detected by MTBDRsl assay
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D94G
Confers Resistance To
Organisms Observed In
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
PMID 20713679 · 2010Previously reported
Mutation Information
- Gene Name
- gyrA
- Protein Change
- R128S
Confers Resistance To
Organisms Observed In
Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007.
PMID 20113512 · 2010Multiple substitutions observed, including Ser83→Phe, Ser83→Pro, Ser83→Tyr, Asp87→Gly, and Asp87→Asn.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.
PMID 20435780 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S84L
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D91G
Confers Resistance To
Organisms Observed In
Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.
PMID 20573868 · 2010detected by MTBDRsl assay
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D94N
Confers Resistance To
Organisms Observed In
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
PMID 20713679 · 2010Previously reported
Mutation Information
- Gene Name
- gyrA
- Protein Change
- Y129C
Confers Resistance To
Organisms Observed In
Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007.
PMID 20113512 · 2010Multiple substitutions observed, including Ser83→Phe, Ser83→Pro, Ser83→Tyr, Asp87→Gly, and Asp87→Asn.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83F
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D91Y
Confers Resistance To
Organisms Observed In
Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.
PMID 20573868 · 2010detected by MTBDRsl assay
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A90V
Confers Resistance To
Organisms Observed In
Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi.
PMID 20138477 · 2010All 18 isolates from Laos and the two genome sequences (Boryong and Ikeda) showed the same mutation.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- R140K
Confers Resistance To
Organisms Observed In
The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients.
PMID 20597679 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis.
PMID 20159551 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- G82D
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- V150A
Confers Resistance To
Organisms Observed In
Clostridium difficile Isolates Resistant to Fluoroquinolones in Italy: Emergence of PCR Ribotype 018
PMID 20554809 · 2010Mutation in gyrA confers resistance to fluoroquinolones
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T82I
Confers Resistance To
Organisms Observed In
The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients.
PMID 20597679 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87E
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- V150A
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- N87K
Confers Resistance To
Organisms Observed In
In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B.
PMID 20566759 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Effect on Function
reduced susceptibility to ciprofloxacin
Confers Resistance To
Organisms Observed In
Impact of recA on levofloxacin exposure-related resistance development.
PMID 20660686 · 2010Additional mutations in gyrA (e.g., S84A, S84L, S84P, E88G, and E88K) were found in all the levofloxacin-resistant isolates.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
PMID 20713679 · 2010Previously reported
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D94G
Confers Resistance To
Organisms Observed In
Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.
PMID 20458765 · 2010Mutations in the gyrA gene were associated with fluoroquinolone resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- N87Y
Confers Resistance To
Organisms Observed In
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
PMID 20713679 · 2010Previously reported
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A90V
Confers Resistance To
Organisms Observed In
In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B.
PMID 20566759 · 2010Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Effect on Function
reduced susceptibility to ciprofloxacin
Confers Resistance To
Organisms Observed In
Impact of recA on levofloxacin exposure-related resistance development.
PMID 20660686 · 2010Additional mutations in gyrA (e.g., S84A, S84L, S84P, E88G, and E88K) were found in all the levofloxacin-resistant isolates.
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
PMID 20713679 · 2010Previously reported
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S95T
Confers Resistance To
Organisms Observed In
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
PMID 20713679 · 2010Previously reported
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D94N
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- A70T
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli.
PMID 18031331 · 2007Phenotype described only in association with other mutations (T86), unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D85Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83R
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90T
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli.
PMID 18031331 · 2007Phenotype described only in association with other mutations (T86), unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D85Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90T
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- G81C
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90T
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90T
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- A70T
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90T
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.
PMID 10508034 · 1999Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S97N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83R
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.
PMID 8891148 · 1996Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Phenotype described only in association with other mutations (R285), unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- P104S
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90T
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83R
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- G81D
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics.
PMID 8980760 · 1997D82G mutation confers resistance to ciprofloxacin only. If D82G and G81D are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D82G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83W
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- T86V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
PMID 8384814 · 1993Mutation Information
- Gene Name
- gyrA
- Protein Change
- D90N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
PMID 16713726 · 2006Phenotype described only in association with other mutations (R285), unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- P104S
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83R
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.
PMID 8392306 · 1993G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- G81C
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83I
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.
PMID 8392306 · 1993G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- G81C
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83W
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990Unknown phenotype if Q106H occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- Q106R
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
PMID 9527801 · 1998Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990Mutation Information
- Gene Name
- gyrA
- Protein Change
- A67S
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.
PMID 8392306 · 1993G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- G81D
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83W
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87K
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87L
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- G81C
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics.
PMID 8980760 · 1997D82G mutation confers resistance to ciprofloxacin only. If D82G and G81D are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D82G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.
PMID 8891148 · 1996Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Unknown phenotype if A196E occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A196E
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
PMID 12373497 · 2002Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- E87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.
PMID 10508034 · 1999Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- S97N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.
PMID 8392306 · 1993G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- G81D
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.
PMID 8891148 · 1996Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.
PMID 11451702 · 2001Unknown phenotype if A84P or A84V occur alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A84P
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
PMID 1850972 · 1991D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990Unknown phenotype if Q106H occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- Q106H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.
PMID 11451702 · 2001Mutation Information
- Gene Name
- gyrA
- Protein Change
- A51V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance
Mutation Information
- Gene Name
- gyrA
- Protein Change
- G81D
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.
PMID 8891148 · 1996Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83W
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.
PMID 7840592 · 1994Unknown phenotype if A84P or A84V occur alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A84V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87N
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
PMID 22878251 · 2012D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87G
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87H
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87V
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
PMID 2168148 · 1990Mutation Information
- Gene Name
- gyrA
- Protein Change
- S83A
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.
PMID 7840592 · 1994Unknown phenotype if A84P or A84V occur alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations
Mutation Information
- Gene Name
- gyrA
- Protein Change
- A84P
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
PMID 12654733 · 2003D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Mutation Information
- Gene Name
- gyrA
- Protein Change
- D87Y
Effect on Function
Target modification
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- A258C
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- A259G
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- A259G
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- A259G
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- A259G
Confers Resistance To
Organisms Observed In
Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.
PMID 14706091 · 2004Most frequent mutation
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- A261G
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- A271T
Confers Resistance To
Organisms Observed In
In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci.
PMID 17938189 · 2008Mutation detected in quinolone-resistant strains
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- AGT -> TTC
- Protein Change
- S81F
Confers Resistance To
Organisms Observed In
A predominant multidrug-resistant Salmonella enterica serovar Saintpaul clonal line in German turkey and related food products.
PMID 20363784 · 2010Mutation in the quinolone resistance-determining region
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- AGT->GAA
Confers Resistance To
Organisms Observed In
Multiplex strategy for multilocus sequence typing, fla typing, and genetic determination of antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates collected in Switzerland.
PMID 19439549 · 2009mutation in gyrA confers quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- C257T
- Protein Change
- S86L
Confers Resistance To
Organisms Observed In
Multiplex strategy for multilocus sequence typing, fla typing, and genetic determination of antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates collected in Switzerland.
PMID 19439549 · 2009mutation in gyrA confers quinolone resistance
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- C257T
- Protein Change
- S86L
Confers Resistance To
Organisms Observed In
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
PMID 11266291 · 2001Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G210A
Confers Resistance To
Organisms Observed In
Dynamics of Long-Term Colonization of Respiratory Tract by Haemophilus influenzae in Cystic Fibrosis Patients Shows a Marked Increase in Hypermutable Strains.
PMID 15070988 · 2004Mutations in gyrA were associated with ciprofloxacin resistance.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G244C
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G247A
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G247A
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G247C
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G247C
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G248A
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G248A
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G248T
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G248T
Confers Resistance To
Organisms Observed In
Emerging nalidixic acid and ciprofloxacin resistance in non-typhoidal Salmonella isolated from patients having acute diarrhoeal disease.
PMID 15387492 · 2004Mutations in gyrA were associated with quinolone resistance.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G249A
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States FoodNet multicenter retrospective cohort study.
PMID 18212096 · 2008Mutations in gyrA were associated with decreased susceptibility to fluoroquinolones.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G249T
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G259A
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G259A
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G260A
Confers Resistance To
Organisms Observed In
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
PMID 20511368 · 2010Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G260A
Confers Resistance To
Organisms Observed In
Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency.
PMID 15980348 · 2005Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G262T
- Protein Change
- D88Y
Confers Resistance To
Organisms Observed In
In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.
PMID 17938193 · 2007Detected in mice treated with 0.25% MXF
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G281A
- Protein Change
- D94N
Confers Resistance To
Organisms Observed In
Detection of Ciprofloxacin-Resistant Yersinia pestis by Fluorogenic PCR Using the LightCycler.
PMID 11574586 · 2001Mutant M1
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- G81A
Confers Resistance To
Organisms Observed In
Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.
PMID 15364994 · 2004Single nucleotide exchange at position 83
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- GAT->AAT
- Protein Change
- D87N
Confers Resistance To
Organisms Observed In
Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.
PMID 15364994 · 2004Single nucleotide exchange at position 83
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- GAT->GGT
- Protein Change
- D87G
Confers Resistance To
Organisms Observed In
Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.
PMID 15364994 · 2004Single nucleotide exchange at position 83
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- GAT->TAT
- Protein Change
- D87Y
Confers Resistance To
Organisms Observed In
In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.
PMID 18443108 · 2008Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- T1560A
Confers Resistance To
Organisms Observed In
Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.
PMID 18838592 · 2009Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- T248A
Confers Resistance To
Organisms Observed In
Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.
PMID 18838592 · 2009Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- T260A
Confers Resistance To
Organisms Observed In
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.
PMID 17986343 · 2007The serine-containing GyrA protein confers resistance to ciprofloxacin.
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- T84C
- Protein Change
- L84S
Confers Resistance To
Organisms Observed In
Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.
PMID 15364994 · 2004Single nucleotide exchange at position 83
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- TCA->CTA
- Protein Change
- S83L
Confers Resistance To
Organisms Observed In
Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.
PMID 14706091 · 2004Most frequent mutation
Mutation Information
- Gene Name
- gyrA
- Nucleotide Change
- TCC->CTC