Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.

PMID: 106393792000

Key Findings

The study identifies a point mutation in the promoter region of the aac(3)-Xa gene in Streptomyces griseus SS-1198, which increases the transcription level of the gene and leads to kanamycin resistance.

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3gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
aac(3)-Xa	1	aminoglycoside 3-N-acetyltransferase	KanamycinAMINOGLYCOSIDE	Streptomyces griseus SS-1198 Streptomyces lividans TK21 Streptomyces griseus	Card DatabaseReference Gene CatalogReslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
aac(3)-Xa	-	C-12T	-	Streptomyces lividans, Streptomyces griseus	-	Reslit	-

Browse Papers

Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.

AMR Genes

AMR Mutations