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pncA Mutations as a Major Mechanism of Pyrazinamide Resistance in Mycobacterium tuberculosis: Spread of a Monoresistant Strain in Quebec, Canada.

PMID: 106813132000

Key Findings

The study confirms that pncA mutations are the major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

0gene entries

21mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA	D12A	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V155G	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	R140S	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	ReslitCard Database	-
pncA	D53A	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	ReslitCard Database	-
pncA	T168N	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	ReslitCard Database	-
pncA	G97S	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	ReslitCard Database	-
pncA	Q10R	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V130G	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	W68*	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	H82R	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	ReslitCard Database	-
pncA	A46V	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	ReslitCard Database	-
pncA	L85R	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	C138S	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	Card Database	-
pncA	H71E	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	Card Database	-
pncA	A134V	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	Card Database	-