pncA
Overview
- Papers
- 5
- Mutations
- 23
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| L19R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| I31S | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| I31T | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| L27P | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| D53A | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| Q10R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| G132D | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| H82R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| H51R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| L85R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| D12A | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| V155G | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| R140S | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| T168N | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| G97S | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| V130G | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| W68* | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| A46V | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| G132A | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| T47A | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
Surveillance of pyrazinamide susceptibility among multidrug-resistant Mycobacterium tuberculosis isolates from Siriraj Hospital, Thailand.
Some mutations were not associated with resistance and could lead to misinterpretation of the genotypic methods.
Mutation Information
- Protein Change
- L19R, I31S, I31T, L27P
- Nucleotide Change
- A-11C, A-11G
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- pyrazinamide
- Source Database
- Reslit
pncA Mutations as a Major Mechanism of Pyrazinamide Resistance in Mycobacterium tuberculosis: Spread of a Monoresistant Strain in Quebec, Canada.
The study confirms that pncA mutations are the major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.
Mutation Information
- Protein Change
- D53A, Q10R, H82R, L85R, D12A, V155G, R140S, T168N, G97S, V130G, W68*, A46V
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- pyrazinamide
- Source Database
- Reslit
Genetic diversity and evidence for acquired antimicrobial resistance in Mycobacterium tuberculosis at a large hospital in South India.
Mutation Information
- Protein Change
- G132D, H51R
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- pyrazinamide
- Source Database
- Reslit
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.
Mutation Information
- Protein Change
- G132A
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- pyrazinamide
- Source Database
- Reslit
Phenotypic characterization of pncA mutants of Mycobacterium tuberculosis.
includes various types of mutations
Mutation Information
- Protein Change
- T47A
- Nucleotide Change
- A139G, T-7C
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- pyrazinamide
- Source Database
- Reslit