A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.

PMID: 108177402000Japan

Key Findings

The study identifies a novel SHV-derived extended-spectrum beta-lactamase, SHV-24, which confers high-level resistance to ceftazidime through a single amino acid substitution (D179G) in the omega-loop of the enzyme.

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5gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaSHV	1	extended-spectrum beta-lactamase	CeftazidimeAZTREONAMTICARCILLINCEPHALOSPORINAMOXICILLINCEFEPIMEAMPICILLINCEFOTAXIMECEFTAZIDIME+2 more	Escherichia coli	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	-

Browse Papers

A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.

AMR Genes