Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.

PMID: 111209752001

Key Findings

The study identified msrC, a species-specific gene in Enterococcus faecium, which contributes to macrolide resistance. Disruption of msrC led to increased susceptibility to erythromycin, azithromycin, tylosin, and quinupristin.

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7gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
msr(C)	3	ABC transporter	ErythromycinAzithromycinTylosinQuinupristinTYLOSINSTREPTOGRAMIN BQUINUPRISTINPRISTINAMYCIN IAAZITHROMYCIN+3 more	Enterococcus faecium	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	-

Browse Papers

Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.

AMR Genes