Novel Cefotaximase (CTX-M-16) with Increased Catalytic Efficiency Due to Substitution Asp-240→Gly.

PMID: 114516842001Brazil

Key Findings

The study identifies a novel CTX-M-type beta-lactamase, CTX-M-16, which differs from CTX-M-9 by a single amino acid substitution (Asp-240→Gly). This mutation enhances the catalytic efficiency of the enzyme, particularly against ceftazidime and aztreonam.

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5gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCTX-M	1	beta-lactamase	CeftazidimeCefotaximeAZTREONAMTICARCILLINCEPHALOSPORINAMOXICILLINCEFEPIMEAMPICILLINCEFOTAXIME+3 more	Escherichia coli	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	-

Browse Papers

Novel Cefotaximase (CTX-M-16) with Increased Catalytic Efficiency Due to Substitution Asp-240→Gly.

AMR Genes