Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA.

PMID: 114516952001

Key Findings

Thirteen isolates showed the same nucleotide transition (ACT→ATT) resulting in a threonine→isoleucine change. In one isolate (1542), two nucleotide changes (ACT→GTT) resulted in a replacement of threonine by valine.

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0gene entries

2mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	T83I	-	-	Clostridium difficile	Moxifloxacin	Reslit	-
gyrA	T82V	-	DNA gyrase subunit A GyrA	Clostridioides difficile	QUINOLONE	Reference Gene Catalog	-

Browse Papers

Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA.

AMR Mutations