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Key Findings
Mutations in parC were linked to nalidixic acid resistance.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| S80I | - | DNA topoisomerase IV subunit A ParC | Escherichia coli | Nalidixic acidQUINOLONE | ReslitReference Gene Catalog | - | |
| S83L | - | DNA gyrase subunit A GyrA | Escherichia coli | Nalidixic acidQUINOLONE | ReslitReference Gene Catalog | - | |
| D107E | - | - | Escherichia coli | Nalidixic acid | Reslit | - | |
| S83A | - | DNA gyrase subunit A GyrA | Escherichia coli | QUINOLONE | Reference Gene Catalog | - | |
| D87N | - | DNA gyrase subunit A GyrA | Escherichia coli | QUINOLONE | Reference Gene Catalog | - | |
| E84G | - | DNA topoisomerase IV subunit A ParC | Escherichia coli | QUINOLONE | Reference Gene Catalog | - |
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