CTX-M-Type Extended-Spectrum β-Lactamase That Hydrolyzes Ceftazidime through a Single Amino Acid Substitution in the Omega Loop.

PMID: 117093082001France

Key Findings

The study identified two CTX-M-type beta-lactamases, CTX-M-18 and CTX-M-19, which confer resistance to various beta-lactam antibiotics, with CTX-M-19 showing unique resistance to ceftazidime due to a single amino acid substitution in the omega loop.

View on PubMed

6gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCTX-M	2	beta-lactamase	CefotaximeCeftazidimeAztreonamAZTREONAMTICARCILLINCEPHALOSPORINAMOXICILLINCEFEPIMEAMPICILLIN+4 more	Escherichia coli Klebsiella pneumoniae	Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Browse Papers

CTX-M-Type Extended-Spectrum β-Lactamase That Hydrolyzes Ceftazidime through a Single Amino Acid Substitution in the Omega Loop.

AMR Genes