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Type II topoisomerase quinolone resistance-determining regions of Aeromonas caviae, A. hydrophila, and A. sobria complexes and mutations associated with quinolone resistance.

PMID: 117963412002

Key Findings

Mutations at positions 80 and 84 in parC lead to quinolone resistance.

0gene entries

12mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	S80I	-	-	Aeromonas caviae, Aeromonas hydrophila, Aeromonas sobria	Nalidixic acid\|Oxolinic acid\|Pipemidic acid\|Flumequine\|Norfloxacin\|Pefloxacin\|Ofloxacin\|Sparfloxacin\|Ciprofloxacin\|Enrofloxacin	Reslit	-
parC	E84K	-	-	Aeromonas caviae, Aeromonas hydrophila, Aeromonas sobria	Nalidixic acid\|Oxolinic acid\|Pipemidic acid\|Flumequine\|Norfloxacin\|Pefloxacin\|Ofloxacin\|Sparfloxacin\|Ciprofloxacin\|Enrofloxacin	Reslit	-
gyrA	S83I	-	confers resistance	Aeromonas caviae, A. hydrophila, A. sobria	Nalidixic acid\|Oxolinic acid\|Pipemidic acid\|Flumequine\|Norfloxacin\|Pefloxacin\|Ofloxacin\|Sparfloxacin\|Ciprofloxacin\|Enrofloxacin	Reslit	-
parC	S80R	-	-	Aeromonas caviae, Aeromonas hydrophila, Aeromonas sobria	Nalidixic acid\|Oxolinic acid\|Pipemidic acid\|Flumequine\|Norfloxacin\|Pefloxacin\|Ofloxacin\|Sparfloxacin\|Ciprofloxacin\|Enrofloxacin	Reslit	-