Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa.

Key Findings

The study identifies a novel variant of the metallo-beta-lactamase gene bla(VIM-1), termed bla(VIM-4), in a carbapenem-resistant Pseudomonas aeruginosa strain. This variant differs by a single nucleotide from bla(VIM-1), leading to a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme.