Browse Papers

Explore scientific publications on antimicrobial resistance

Mutations Affecting DNA-Binding Activity of the MexR Repressor of mexR-mexA-mexB-oprM Operon Expression.

PMID: 145260322003

Key Findings

Mutations in mexR lead to derepression of the mexAB-oprM efflux pump, resulting in increased resistance to aztreonam and ofloxacin.

0gene entries

24mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mexR	T69I	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	R91C	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	L45P	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	I72N	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	R91H	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	I46N	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	L75P	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	L57P	-	effux pump transcriptional repressor MexR, single resistance variant	Pseudomonas aeruginosa	Aztreonam\|OfloxacinAZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM	ReslitReference Gene CatalogCard Database	-
mexR	L75R	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	L57R	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	R83C	-	single resistance variant	Pseudomonas aeruginosa	Aztreonam\|Ofloxacin	ReslitCard Database	-
mexR	H107P	-	single resistance variant	Pseudomonas aeruginosa	-	Card Database	-