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Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan.

PMID: 151552282004

Key Findings

observed in 18 of 19 strains

0gene entries

8mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp2b	T451A	-	resistance	Streptococcus pneumoniae	Penicillin	Reslit	-
pbp1a	T574N	-	reduced affinity for β-lactam antibiotics	Streptococcus pneumoniae	Penicillin	Reslit	-
pbp2b	E481G	-	resistance	Streptococcus pneumoniae	Penicillin	Reslit	-
pbp1a	S575T	-	reduced affinity for β-lactam antibiotics	Streptococcus pneumoniae	Penicillin	Reslit	-
pbp1a	F577Y	-	reduced affinity for β-lactam antibiotics	Streptococcus pneumoniae	Penicillin	Reslit	-
pbp1a	T371S	-	reduced affinity for β-lactam antibiotics	Streptococcus pneumoniae	Penicillin	Reslit	-
pbp2b	T624G	-	resistance	Streptococcus pneumoniae	Imipenem	Reslit	-
pbp1a	Q576G	-	reduced affinity for β-lactam antibiotics	Streptococcus pneumoniae	Penicillin	Reslit	-