Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

PMID: 152730992004Japan

Key Findings

The study identifies GES-4, a class A beta-lactamase with a G170S substitution in the omega-loop, which confers resistance to cephamycins and carbapenems and exhibits inhibitor resistance.

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5gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaGES	1	class A beta-lactamase	CefoxitinImipenemMeropenemTICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEM+3 more	Klebsiella pneumoniae Escherichia coli	Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Browse Papers

Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

AMR Genes