Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutants.

PMID: 156503702004

Key Findings

The Arg418->Gln mutation in KatG leads to loss of catalase-peroxidase activities and confers isoniazid resistance.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
katG	R418Q	-	loss of catalase-peroxidase activities	Mycobacterium tuberculosis	Isoniazid	Reslit	-