ResLit logoResLit

katG

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
AMR Rules
Browse AMR rules for katG
Validation StatusCandidate

Overview

Papers
12
Mutations
38

Mutations

Protein ChangeNucleotide ChangeMechanismOrganismResistance ToDatabaseValidation Status
L463R--Mycobacterium bovis
isoniazid
Reslit
Candidate
S315T--Mycobacterium bovis, Mycobacterium tuberculosis
isoniazid
Reslit
Supported
E506K--Mycobacterium bovis
isoniazid
Reslit
Candidate
G428R--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
R463L--Mycobacterium tuberculosis
isoniazid
Reslit
Supported
D328A--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
R418Q-loss of catalase-peroxidase activitiesMycobacterium tuberculosis
isoniazid
Reslit
Candidate
S315N--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
M257I--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
G491C--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
D117A--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
T275P--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
R104L--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
T275V--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
W107R--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
W300G--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
W107F--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
S315G--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
H108E--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
S315I--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
H108Q--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
D735N--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
T262R--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
W328F--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
N138D--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
S315R--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
M255C--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
N138S--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
M255I--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
Y229F--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
W328G--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
M255Y--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
Y337C--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
A350S--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
E217G--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
L587M--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
G629S--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
D329A--Mycobacterium tuberculosis
isoniazid
Reslit
Candidate
Papers12
1

Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.

PMID 11353606 · 2001

Mutation Information

katG: p.L463RkatG: p.S315TkatG: p.E506K
Protein Change
L463R, S315T, E506K
Organisms
Mycobacterium bovis
Confers Resistance To
isoniazid
Source Database
Reslit
2

Genetic diversity and evidence for acquired antimicrobial resistance in Mycobacterium tuberculosis at a large hospital in South India.

PMID 11179917 · 2000

Mutation Information

katG: p.G428RkatG: p.D328A
Protein Change
G428R, D328A
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
3

Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.

PMID 11796356 · 2002

Mutation Information

katG: p.R463L
Protein Change
R463L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
4

Evaluation of the invader assay, a linear signal amplification method, for identification of mutations associated with resistance to rifampin and isoniazid in Mycobacterium tuberculosis.

PMID 10770765 · 2000

Mutation Information

katG: p.S315T
Protein Change
S315T
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
5

Rapid direct detection of multiple rifampin and isoniazid resistance mutations in Mycobacterium tuberculosis in respiratory samples by real-time PCR.

PMID 15504855 · 2004

Mutation Information

katG: p.S315TkatG: p.S315N
Protein Change
S315T, S315N
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
6

Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutants.

PMID 15650370 · 2004

The Arg418->Gln mutation in KatG leads to loss of catalase-peroxidase activities and confers isoniazid resistance.

Mutation Information

katG: p.R418Q
Protein Change
R418Q
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Effect on Function
loss of catalase-peroxidase activities
Source Database
Reslit
7

Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates collected in Australia.

PMID 16189082 · 2005

Three novel katG mutations (D117A, M257I, G491C) were identified in three INH-resistant strains with a wild-type katG codon 315, fabG1-inhA regulatory region, and inhA structural gene.

Mutation Information

katG: p.M257IkatG: p.G491CkatG: p.D117A
Protein Change
M257I, G491C, D117A
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
8

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

PMID 19890396 · 2009

Mutation Information

katG: p.S315T
Protein Change
S315T
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
9

Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.

PMID 20054829 · 2010

Mutations in KatG are associated with isoniazid resistance through reduced INH-NADH adduct formation.

Mutation Information

katG: p.T275PkatG: p.R104LkatG: p.T275VkatG: p.W107RkatG: p.W300GkatG: p.W107FkatG: p.S315GkatG: p.H108EkatG: p.S315IkatG: p.H108QkatG: p.S315NkatG: p.D735NkatG: p.T262RkatG: p.W328FkatG: p.N138DkatG: p.S315RkatG: p.M255CkatG: p.N138SkatG: p.S315TkatG: p.M255IkatG: p.Y229FkatG: p.W328GkatG: p.M255YkatG: p.Y337CkatG: p.A350SkatG: p.R463LkatG: p.L587MkatG: p.G629S
Protein Change
T275P, R104L, T275V, W107R, W300G, W107F, S315G, H108E, S315I, H108Q, S315N, D735N, T262R, W328F, N138D, S315R, M255C, N138S, S315T, M255I, Y229F, W328G, M255Y, Y337C, A350S, R463L, L587M, G629S
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
10

Validation of the GenoType MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam.

PMID 20525271 · 2010

Mutation Information

katG: p.S315T
Protein Change
S315T
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
11

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

This study

Mutation Information

katG: p.E217GkatG: p.S315TkatG: p.R463LkatG: p.D329A
Protein Change
E217G, S315T, R463L, D329A
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit
12

Rapid screening of MDR-TB using molecular Line Probe Assay is feasible in Uganda.

PMID 20187922 · 2010

Mutation Information

katG: p.S315T
Protein Change
S315T
Organisms
Mycobacterium tuberculosis
Confers Resistance To
isoniazid
Source Database
Reslit