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Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics.

PMID: 158055252005

Key Findings

Mutations in the rpoB gene encoding the beta subunit of RNA polymerase confer resistance to rifampin and related antibiotics.

0gene entries

11mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	D516N	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	S522F	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	H526Y	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	Q513L	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	R529C	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	R687H	-	-	Escherichia coli	Rifampin	Reslit	-
rpoB	Q513P	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	S531F	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	T563P	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	P564L	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-
rpoB	I572F	-	-	Escherichia coli	Rifampin\|Rifabutin\|Rifapentine	Reslit	-