rpoB

Validation StatusCandidate

Overview

Papers: 36
Mutations: 122

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R529S	-	Target modification	Escherichia coli	Rifampicin	ResFinder	Established
D435G	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
L452P	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
I1106T	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
R505K	-	-	Clostridium difficile	rifampinrifampin\|rifaximin	Reslit	Candidate
S531L	T531C	-	Mycobacterium tuberculosis	rifampicinrifampinrifampicin\|rifabutin	Reslit	Supported
H552L	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
D516V	G516T	-	Mycobacterium tuberculosis	rifampinrifampicin	Reslit	Supported
H552Y	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
H526Y	-	Target modification	Mycobacterium tuberculosis, Escherichia coli	rifampinRifampicinrifampin\|rifabutin\|rifapentine\|sorangicin A+1 more	ResFinderReslit	Confirmed
S557F	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
D542V	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
D542N	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
G560S	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
S548F	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
H552N	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
L511V	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
H552R	-	-	Neisseria meningitidis	rifampin	Reslit	Candidate
Q510P	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
P564L	-	Target modification	Escherichia coli	Rifampicinrifampin\|rifabutin\|rifapentine	ResFinderReslit	Confirmed
Q513L	C513T	Target modification	Escherichia coli, Mycobacterium tuberculosis	Rifampicinrifampin\|rifabutin\|rifapentinerifampin	ResFinderReslit	Confirmed
I572F	-	Target modification	Escherichia coli, Mycobacterium tuberculosis	Rifampicinrifampin\|rifabutin\|rifapentinerifampin	ResFinderReslit	Confirmed
I572N	-	Target modification	Escherichia coli	Rifampicin	ResFinder	Established
R529C	-	Target modification	Escherichia coli	Rifampicinrifampin\|rifabutin\|rifapentine	ResFinderReslit	Confirmed
T563P	-	Target modification	Escherichia coli	Rifampicinrifampin\|rifabutin\|rifapentine	ResFinderReslit	Confirmed
R687H	-	Target modification	Escherichia coli	Rifampicinrifampin	ResFinderReslit	Confirmed
Q513P	-	Target modification	Escherichia coli	Rifampicinrifampin\|rifabutin\|rifapentine	ResFinderReslit	Confirmed
L533P	-	Target modification	Escherichia coli	Rifampicin	ResFinder	Established
H540N	-	Target modification	Helicobacter pylori	Rifampicin	ResFinder	Established
V146F	-	Target modification	Escherichia coli, Mycobacterium tuberculosis	Rifampicinrifampinrifabutin	ResFinderReslit	Confirmed
S531F	-	Target modification	Escherichia coli, Mycobacterium tuberculosis	Rifampicinrifampinrifampin\|rifabutin\|rifapentine	ResFinderReslit	Confirmed
I572L	-	Target modification	Escherichia coli, Mycobacterium tuberculosis	Rifampicinrifampin	ResFinderReslit	Confirmed
K527Q	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
D473N	-	-	Listeria monocytogenes	rifampin	Reslit	Candidate
S492L	-	-	Escherichia coli	rifampin	Reslit	Candidate
S530Y	-	-	Listeria monocytogenes	rifampin	Reslit	Candidate
H526P	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
L521P	-	-	Mycobacterium bovis	rifampin	Reslit	Candidate
D473G	-	-	Listeria monocytogenes	rifampin	Reslit	Candidate
V176F	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
H481N	-	-	Staphylococcus aureus	rifampin	Reslit	Candidate
G479D	-	-	Listeria monocytogenes	rifampin	Reslit	Candidate
H483Y	-	-	Listeria monocytogenes	rifampin	Reslit	Candidate
H483L	-	-	Listeria monocytogenes	rifampin	Reslit	Candidate
D516E	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
S416F	-	-	Mycobacterium ulcerans	rifampin	Reslit	Candidate
I528F	-	-	Listeria monocytogenes	rifampin	Reslit	Candidate
S522L	-	-	Mycobacterium tuberculosis	rifampinrifampicin	Reslit	Candidate
H420Y	-	-	Mycobacterium ulcerans	rifampin	Reslit	Candidate
H471L	-	-	Chlamydia trachomatis	rifampin	Reslit	Candidate
H526N	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
S531Y	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
E641E	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
A467T	-	-	Chlamydia trachomatis	rifampin	Reslit	Candidate
G438G	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
S531W	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
P646S	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
H471Y	-	-	Chlamydia trachomatis	rifampin	Reslit	Candidate
H526R	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
V642A	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
Q510H	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
H526D	C526G	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
P646L	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
H471N	-	-	Chlamydia trachomatis	rifampin	Reslit	Candidate
S526A	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
P622Q	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
H511Y	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
H526C	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
D516N	-	-	Escherichia coli	rifampin\|rifabutin\|rifapentine	Reslit	Candidate
L511P	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
E562L	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
I517M	-	-	Chlamydia trachomatis	rifampin	Reslit	Candidate
S522F	-	-	Escherichia coli	rifampin\|rifabutin\|rifapentine	Reslit	Candidate
D516G	G516C	-	Mycobacterium tuberculosis	rifampin	Reslit	Supported
H526S	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
P564S	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
D461N	-	-	Chlamydia trachomatis	rifampin	Reslit	Candidate
D516Y	G516A	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
H526L	-	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
V466A	-	-	Chlamydia trachomatis	rifampin	Reslit	Candidate
Q148H	-	-	Mycobacterium tuberculosis	rifabutin	Reslit	Candidate
L466S	-	-	Staphylococcus aureus	rifampin	Reslit	Candidate
A477D	-	-	Staphylococcus aureus	rifampin	Reslit	Candidate
V850A	-	-	Staphylococcus aureus	rifampin	Reslit	Candidate
V144M	-	-	Mycobacterium tuberculosis	rifabutin	Reslit	Candidate
M1249I	-	-	Brucella melitensis	rifampin	Reslit	Candidate
S529L	-	-	Staphylococcus aureus	rifampin	Reslit	Candidate
H481Y	-	-	Staphylococcus aureus	rifampin	Reslit	Candidate
F505L	-	-	Mycobacterium tuberculosis	rifabutin	Reslit	Candidate
S512G	-	-	Mycobacterium tuberculosis	rifabutin	Reslit	Candidate
L525P	-	Target modification	Helicobacter pylori	Rifampicin	ResFinder	Established
S467F	-	-	Chlamydia trachomatis	rifampin	Reslit	Candidate
H502Y	-	-	Clostridium difficile	rifampin\|rifaximin	Reslit	Candidate
H502N	-	-	Clostridium difficile	rifampin\|rifaximin	Reslit	Candidate
H502R	-	-	Clostridium difficile	rifampin\|rifaximin	Reslit	Candidate
S488T	-	-	Clostridium difficile	rifampin\|rifaximin	Reslit	Candidate
I548M	-	-	Clostridium difficile	rifampin\|rifaximin	Reslit	Candidate
D435Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
-	A547T	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
S456L	AGT->CTT	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
-	C150A	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	C486A	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	C486T	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	C499A	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	C499G	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	C499T	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	C501T	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	C531T	-	Mycobacterium tuberculosis	rifampin	Reslit	Candidate
-	C535G	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	C537T	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	CAG -> TAT	-	Neisseria meningitidis	rifampin	Reslit	Candidate
-	G489A	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	G489C	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	G489T	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	G638A	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	T481C	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	T482C	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	T485C	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	T495C	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	T498C	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	T506A	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate
-	T506C	-	Streptococcus pneumoniae	rifampin	Reslit	Candidate

Papers36

Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance.

PMID 3050121 · 1988

Mutation Information

rpoB: p.R529S rpoB: p.P564L rpoB: p.Q513L rpoB: p.R529C rpoB: p.T563P rpoB: p.R687H rpoB: p.Q513P rpoB: p.L533P rpoB: p.V146F rpoB: p.S531F rpoB: p.H526Y

Protein Change: R529S, P564L, Q513L, R529C, T563P, R687H, Q513P, L533P, V146F, S531F, H526Y
Organisms: Escherichia coli
Confers Resistance To: Rifampicin
Effect on Function: Target modification
Source Database: ResFinder

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

PMID 19890396 · 2009

Mutation Information

rpoB: p.D435G rpoB: p.L452P rpoB: p.I1106T rpoB: p.D435Y

Protein Change: D435G, L452P, I1106T, D435Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital.

PMID 19140738 · 2009

All rifampin-resistant isolates contained the R505K substitution

Mutation Information

rpoB: p.R505K

Protein Change: R505K
Organisms: Clostridium difficile
Confers Resistance To: rifampin
Source Database: Reslit

Validation of the GenoType MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam.

PMID 20525271 · 2010

Mutation Information

rpoB: p.S531L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

Multicenter study for defining the breakpoint for rifampin resistance in Neisseria meningitidis by rpoB sequencing.

PMID 20606072 · 2010

Mutations in rpoB are associated with rifampin resistance in N. meningitidis.

Mutation Information

rpoB: p.H552L rpoB: p.H552Y rpoB: p.S557F rpoB: p.D542V rpoB: p.D542N rpoB: p.G560S rpoB: p.S548F rpoB: p.H552N rpoB: p.H552R

Protein Change: H552L, H552Y, S557F, D542V, D542N, G560S, S548F, H552N, H552R
Organisms: Neisseria meningitidis
Confers Resistance To: rifampin
Source Database: Reslit

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

rpoB: p.D516V rpoB: p.H526Y rpoB: p.S531L rpoB: p.L511V rpoB: p.Q510P

Protein Change: D516V, H526Y, S531L, L511V, Q510P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Rapid screening of MDR-TB using molecular Line Probe Assay is feasible in Uganda.

PMID 20187922 · 2010

Mutation Information

rpoB: p.D516V

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

Drug resistant Mycobacterium tuberculosis of the Beijing genotype does not spread in Sweden.

PMID 20531942 · 2010

associated with multidrug resistance

Mutation Information

rpoB: p.S531L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress.

PMID 23433244 · 2013

Mutation Information

rpoB: p.I572F rpoB: p.I572N rpoB: p.I572L

Protein Change: I572F, I572N, I572L
Organisms: Escherichia coli
Confers Resistance To: Rifampicin
Effect on Function: Target modification
Source Database: ResFinder

Genetic Determinants and Prediction of Antibiotic Resistance Phenotypes in Helicobacter pylori.

PMID 30621024 · 2019

Mutation Information

rpoB: p.H540N rpoB: p.L525P

Protein Change: H540N, L525P
Organisms: Helicobacter pylori
Confers Resistance To: Rifampicin
Effect on Function: Target modification
Source Database: ResFinder

Genetic diversity and evidence for acquired antimicrobial resistance in Mycobacterium tuberculosis at a large hospital in South India.

PMID 11179917 · 2000

Mutation Information

rpoB: p.K527Q rpoB: p.H526P rpoB: p.D516E rpoB: p.S522L

Protein Change: K527Q, H526P, D516E, S522L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Isolation of Rifampin-Resistant Mutants of Listeria monocytogenes and Their Characterization by rpoB Gene Sequencing, Temperature Sensitivity for Growth, and Interaction with an Epithelial Cell Line.

PMID 10449475 · 1999

Mutation Information

rpoB: p.D473N rpoB: p.S530Y rpoB: p.D473G rpoB: p.G479D rpoB: p.H483Y rpoB: p.H483L rpoB: p.I528F

Protein Change: D473N, S530Y, D473G, G479D, H483Y, H483L, I528F
Organisms: Listeria monocytogenes
Confers Resistance To: rifampin
Source Database: Reslit

Compensatory evolution in rifampin-resistant Escherichia coli.

PMID 11102350 · 2000

The study focuses on compensatory evolution in rifampin-resistant E. coli, highlighting mutations in the rpoB gene.

Mutation Information

rpoB: p.S492L

Protein Change: S492L
Organisms: Escherichia coli
Confers Resistance To: rifampin
Source Database: Reslit

Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.

PMID 11353606 · 2001

Mutation Information

rpoB: p.L521P

Protein Change: L521P
Organisms: Mycobacterium bovis
Confers Resistance To: rifampin
Source Database: Reslit

Drug-susceptible Mycobacterium tuberculosis Beijing genotype does not develop mutation-conferred resistance to rifampin at an elevated rate.

PMID 12682139 · 2003

Mutations in rpoB gene associated with rifampin resistance

Mutation Information

rpoB: p.S531L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates.

PMID 11136757 · 2001

Detected in one isolate and 5 of 18 RIF-resistant strains with no cluster I mutation

Mutation Information

rpoB: p.V176F

Protein Change: V176F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.

PMID 11796356 · 2002

Mutation Information

rpoB: p.D516V

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Biological cost of rifampin resistance from the perspective of Staphylococcus aureus.

PMID 12384339 · 2002

Mutations in rpoB confer rifampin resistance

Mutation Information

rpoB: p.H481N

Protein Change: H481N
Organisms: Staphylococcus aureus
Confers Resistance To: rifampin
Source Database: Reslit

Evaluation of the invader assay, a linear signal amplification method, for identification of mutations associated with resistance to rifampin and isoniazid in Mycobacterium tuberculosis.

PMID 10770765 · 2000

Mutation Information

rpoB: p.D516V

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice.

PMID 12654651 · 2003

Mutation Information

rpoB: p.S416F rpoB: p.H420Y

Protein Change: S416F, H420Y
Organisms: Mycobacterium ulcerans
Confers Resistance To: rifampin
Source Database: Reslit

Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil.

PMID 15728912 · 2005

Mutation Information

rpoB: p.H471L rpoB: p.A467T rpoB: p.H471Y rpoB: p.H471N rpoB: p.I517M rpoB: p.D461N rpoB: p.V466A

Protein Change: H471L, A467T, H471Y, H471N, I517M, D461N, V466A
Organisms: Chlamydia trachomatis
Confers Resistance To: rifampin
Source Database: Reslit

Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics.

PMID 15805525 · 2005

Mutations in the rpoB gene encoding the beta subunit of RNA polymerase confer resistance to rifampin and related antibiotics.

Mutation Information

rpoB: p.T563P rpoB: p.I572F rpoB: p.P564L rpoB: p.Q513L rpoB: p.R687H rpoB: p.S531F rpoB: p.Q513P rpoB: p.D516N rpoB: p.S522F rpoB: p.R529C rpoB: p.H526Y

Protein Change: T563P, I572F, P564L, Q513L, R687H, S531F, Q513P, D516N, S522F, R529C, H526Y
Organisms: Escherichia coli
Confers Resistance To: rifampin|rifabutin|rifapentinerifampinrifampin|rifabutin|rifapentine|sorangicin A
Source Database: Reslit

Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis.

PMID 15917513 · 2005

all mutations are in the rpoB gene and confer resistance to rifampin

Mutation Information

Protein Change: H526N, S531Y, E641E, G438G, S531W, P646S, V146F, H526R, S531L, V642A, Q510H, H526D, S531F, P646L, D516E, S526A, P622Q, H511Y, H526C, L511P, H526Y, E562L, D516G, H526S, P564S, D516Y, H526L, I572L, D516V, I572F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Multiple rpoB mutants of Mycobacterium tuberculosis and second-order selection.

PMID 15338545 · 2004

Mutations in rpoB are associated with rifampin resistance in M. tuberculosis.

Mutation Information

rpoB: p.S531L rpoB: p.H526Y

Protein Change: S531L, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency.

PMID 15958167 · 2005

Mutations in the rpoB gene were identified through sequencing of gene fragments.

Mutation Information

rpoB: p.Q148H rpoB: p.S522L rpoB: p.H526Y rpoB: p.V144M rpoB: p.S531L rpoB: p.F505L rpoB: p.S512G rpoB: p.V146F

Protein Change: Q148H, S522L, H526Y, V144M, S531L, F505L, S512G, V146F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifabutinrifampicinrifampicin|rifabutin
Source Database: Reslit

Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of rifampin resistance genotypes in relation to clinical prevalence.

PMID 16377701 · 2006

Mutations in the rpoB gene were identified as conferring rifampin resistance in Staphylococcus aureus.

Mutation Information

rpoB: p.L466S rpoB: p.A477D rpoB: p.V850A rpoB: p.H481N rpoB: p.S529L rpoB: p.H481Y

Protein Change: L466S, A477D, V850A, H481N, S529L, H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: rifampin
Source Database: Reslit

Rapid detection of rifampin resistance in Mycobacterium tuberculosis by Pyrosequencing technology.

PMID 16757581 · 2006

Mutations in the rpoB gene are associated with rifampin resistance

Mutation Information

rpoB: p.S531L rpoB: p.L511P rpoB: p.D516G

Protein Change: S531L, L511P, D516G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Molecular epidemiological and antibiotic susceptibility characterization of Brucella isolates from humans in Sicily, Italy.

PMID 17634297 · 2007

The mutation was not associated with the RIF resistance phenotype.

Mutation Information

rpoB: p.M1249I

Protein Change: M1249I
Organisms: Brucella melitensis
Confers Resistance To: rifampin
Source Database: Reslit

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

PMID 18443108 · 2008

Mutation Information

rpoB: p.H481Y

Protein Change: H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: rifampin
Source Database: Reslit

Interstrain gene transfer in Chlamydia trachomatis in vitro: mechanism and significance.

PMID 18083799 · 2008

Mutation Information

rpoB: p.S467F

Protein Change: S467F
Organisms: Chlamydia trachomatis
Confers Resistance To: rifampin
Source Database: Reslit

Rifampin and rifaximin resistance in clinical isolates of Clostridium difficile.

PMID 18559647 · 2008

Mutations in rpoB are associated with rifampin and rifaximin resistance in C. difficile

Mutation Information

rpoB: p.H502Y rpoB: p.H502N rpoB: p.H502R rpoB: p.R505K rpoB: p.S488T rpoB: p.I548M

Protein Change: H502Y, H502N, H502R, R505K, S488T, I548M
Organisms: Clostridium difficile
Confers Resistance To: rifampin|rifaximin
Source Database: Reslit

New mutations and horizontal transfer of rpoB among Rifampin-Resistant Streptococcus pneumoniae from four Spanish hospitals.

PMID 15917517 · 2005

Mutations in rpoB were identified as the cause of rifampin resistance in Streptococcus pneumoniae.

Mutation Information

Nucleotide Change: A547T, C150A, C486A, C486T, C499A, C499G, C499T, C501T, C535G, C537T, G489A, G489C, G489T, G638A, T481C, T482C, T485C, T495C, T498C, T506A, T506C
Organisms: Streptococcus pneumoniae
Confers Resistance To: rifampin
Source Database: Reslit

Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis.

PMID 19300517 · 2009

Mutation Information

rpoB: p.S456L / c.AGT->CTT

Protein Change: S456L
Nucleotide Change: AGT->CTT
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin.

PMID 19146699 · 2009

Some mutations in the rpoB gene can reveal drug-resistant phenotype only in a specific genetic background of the host.

Mutation Information

rpoB: p.Q513L / c.C513T rpoB: p.H526D / c.C526G rpoB: p.D516Y / c.G516A rpoB: p.D516G / c.G516C rpoB: p.D516V / c.G516T rpoB: p.S531L / c.T531C

Protein Change: Q513L, H526D, D516Y, D516G, D516V, S531L
Nucleotide Change: C513T, C526G, G516A, G516C, G516T, T531C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Spread of Drug-Resistant Mycobacterium tuberculosis Strains of the Beijing Genotype in the Archangel Oblast, Russia.

PMID 12037045 · 2002

The 531 TCG→TTG mutation was predominant among strains of the Beijing genotype.

Mutation Information

rpoB: c.C531T

Nucleotide Change: C531T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampin
Source Database: Reslit

Rifampin-resistant meningococcal disease.

PMID 15963302 · 2005

Mutations in the RNA polymerase β subunit (rpoB) gene were found in isolates from each rifampin-resistant case-patient.

Mutation Information

rpoB: c.CAG -> TAT

Nucleotide Change: CAG -> TAT
Organisms: Neisseria meningitidis
Confers Resistance To: rifampin
Source Database: Reslit