Pharmacodynamic activity of telithromycin at simulated clinically achievable free-drug concentrations in serum and epithelial lining fluid against efflux (mefE)-producing macrolide-resistant Streptococcus pneumoniae for which telithromycin MICs vary.

PMID: 158555172005

Key Findings

The study characterizes the mefE gene, which encodes an efflux pump responsible for macrolide resistance in Streptococcus pneumoniae. Telithromycin was effective against mefE-producing strains with MICs up to 0.25 μg/ml in serum and 1 μg/ml in epithelial lining fluid.

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1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mef(En2)	1	efflux pump	macrolides	Streptococcus pneumoniae	Reslit	-

Browse Papers

Pharmacodynamic activity of telithromycin at simulated clinically achievable free-drug concentrations in serum and epithelial lining fluid against efflux (mefE)-producing macrolide-resistant Streptococcus pneumoniae for which telithromycin MICs vary.

AMR Genes