Phenotypic and molecular characterization of Mycobacterium tuberculosis isolates resistant to both isoniazid and ethambutol.

PMID: 159175152005

Key Findings

The paper states that mutations at katG Ser315 mediate high-level resistance to INH.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
katG	S315T	-	The katG Ser315Thr alteration results in an enzyme that cannot activate INH but that still maintains significant catalase-peroxidase activity, thus permitting the INH-resistant organism to survive in the presence of oxidative stress.	Mycobacterium tuberculosis	Isoniazid	Reslit	-