Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.

PMID: 159819992005

Key Findings

The Ser130Gly substitution prevents irreversible cross-linking of the inhibitor to Ser130, leading to resistance.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaTEM-1	S130G	-	prevents irreversible cross-linking of the inhibitor to Ser130	Escherichia coli	Penicillin	Reslit	-