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Pharmacodynamic evidence that ciprofloxacin failure against tuberculosis is not due to poor microbial kill but to rapid emergence of resistance.

PMID: 160489212005

Key Findings

Single-step mutation in gyrA leads to ciprofloxacin resistance

0gene entries

1mutation entry

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S95N	-	-	Mycobacterium tuberculosis	Ciprofloxacin	Reslit	-