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Amino acid mutations essential to production of an altered PBP 2X conferring high-level beta-lactam resistance in a clinical isolate of Streptococcus pneumoniae.

PMID: 162513042005

0gene entries

6mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp2x	Y595F	-	decreased the affinity of the protein for a β-lactam	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	T338P	-	decreased the affinity of the protein for a β-lactam	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	A369V	-	decreased the affinity of the protein for a β-lactam	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	R384G	-	decreased the affinity of the protein for a β-lactam	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	L364F	-	decreased the affinity of the protein for a β-lactam	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	I371T	-	decreased the affinity of the protein for a β-lactam	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-