Horizontal Transfer of blaCMY-bearing plasmids among clinical Escherichia coli and Klebsiella pneumoniae isolates and emergence of cefepime-hydrolyzing CMY-19.

PMID: 164367072006Japan

Key Findings

The study identifies blaCMY-9 and blaCMY-19 genes encoding beta-lactamases that confer resistance to various beta-lactam antibiotics, including cefepime. A single amino acid substitution (I292S) in CMY-19 expands its hydrolytic activity against certain cephalosporins compared to CMY-9.

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6gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaMOX	2	beta-lactamase	CefoxitinCefotaximeCeftazidimePiperacillinAmpicillinTICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITIN+8 more	Escherichia coli Klebsiella pneumoniae	Card DatabaseReference Gene CatalogResFinder Database

Browse Papers

Horizontal Transfer of blaCMY-bearing plasmids among clinical Escherichia coli and Klebsiella pneumoniae isolates and emergence of cefepime-hydrolyzing CMY-19.

AMR Genes