Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.

PMID: 176001512007

Key Findings

Mutations in the cofactor binding site of InhA reduce NADH affinity but have minimal effect on INH-NAD adduct affinity.

0gene entries

3mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
inhA	I47T	A141C	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-
inhA	I21V	A63T	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-
inhA	S94A	T282G	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-