Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
enoyl-(acyl-carrier-protein) reductase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| C15T | - | Mycobacterium tuberculosis | isoniazidethionamide | Reslit | Supported | |
| A16G | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported |
| T8C | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported |
| T8A | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported |
| S105T | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S15T | - | - | - | isoniazid | Reslit | Candidate |
| C15W | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S94A | mutant (S94A) copy of the inhA gene, reduces the effectiveness of INH-NAD inhibition, single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazidethionamideethambutol | Card DatabaseResFinder DatabaseReslit | Confirmed | |
| I21V | reduce NADH affinity, single resistance variant | Mycobacterium tuberculosis | isoniazidethionamide | Card DatabaseResFinder DatabaseReslit | Confirmed | |
| I21T | single resistance variant | Mycobacterium tuberculosis | isoniazidethionamide | Card DatabaseResFinder DatabaseReslit | Confirmed | |
| I95P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card DatabaseResFinder DatabaseReslit | Confirmed |
| I95T | - | - | Mycobacterium tuberculosis | isoniazid | ResFinder DatabaseReslit | Confirmed |
| I194T | single resistance variant | Mycobacterium tuberculosis | isoniazidethionamide | Card DatabaseResFinder DatabaseReslit | Confirmed | |
| V65M | - | - | - | isoniazid | Reslit | Candidate |
| G141R | - | - | - | isoniazid | Reslit | Candidate |
| G183R | - | - | - | isoniazid | Reslit | Candidate |
| A190S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| H265D | - | - | - | isoniazid | Reslit | Candidate |
| V78A | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card DatabaseResFinder DatabaseReslit | Confirmed |
| T15A | - | - | - | isoniazid | Reslit | Candidate |
| I16T | - | reduce NADH affinity, single resistance variant | Mycobacterium tuberculosis | isoniazid | Card DatabaseResFinder DatabaseReslit | Confirmed |
| C15F | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L649L | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R27W | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P251R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| N139S | - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| M161V | - | - | Mycobacterium smegmatis | triclosanisoniazid | Reslit | Candidate |
| M103T | - | - | Mycobacterium smegmatis | triclosan | Reslit | Candidate |
| A124V | - | - | Mycobacterium smegmatis | triclosan | Reslit | Candidate |
| I47T | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card DatabaseResFinder DatabaseReslit | Confirmed | |
| M14I | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| D84N | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| D86N | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R114Q | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A16C | - | - | - | isoniazid | Reslit | Candidate |
| I194A | - | - | - | isoniazid | Reslit | Candidate |
| S531L | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S94P | - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| E15K | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P19L | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| V21I | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G94D | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G194D | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L203L | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P17Q | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P51S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A124E | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L15F | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S16F | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A35V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| K8N | - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Established |
| L11V | - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Established |
| I21N | - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Established |
| G40W | - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Established |
| S94L | - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Established |
| S94W | - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Established |
| G141E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Established |
| T162S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Established |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported | |
| - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate | |
| - | increased production of InhA protein | Mycobacterium tuberculosis, Mycobacterium africanum | isoniazidethionamide | Reslit | Supported | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazidethionamide | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate | |
| L44L | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium bovis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazidethionamide | Reslit | Candidate | |
| L193F | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazidethionamide | Reslit | Supported | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | ethionamideisoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| V136A | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazidethionamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazidethionamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported | |
| - | - | Mycobacterium tuberculosis | isoniazidethionamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| I25T | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Supported |
Rapid screening of MDR-TB using molecular Line Probe Assay is feasible in Uganda.
Research Article
Drug-resistant tuberculosis transmission and resistance amplification within families.
Research Article
Molecular drug susceptibility testing against the first-line (rifampin and isoniazid) and second-line (ciprofloxacin-amikacin and kanamycin) treatment in different subtypes of Mycobacterium simiae.
Research Article
Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages.
Research Article
The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria.
Research Article
The inhA S94A mutation is associated with isoniazid resistance and shows no fitness defect in the absence of DnaJ1 or DnaJ2.
Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
Research Article
The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.
Research Article
Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
Research Article
Mutations in inhA were associated with isoniazid resistance.
Antimicrobial Resistance in Mycobacterium tuberculosis Clinical Isolates from HIV-Positive and HIV-Negative Patients in Russia
Research Article
Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.
Research Article
Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities.
Research Article
Mutations in the glycine-rich loop of InhA reduce NADH affinity, contributing to isoniazid resistance.
Rapid Screening of MDR-TB in Cases of Extra Pulmonary Tuberculosis Using Geno Type MTBDRplus.
Research Article
Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.
Research Article
most common mutation
Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.
Research Article
Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.
Research Article
Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples.
Research Article
Whole genome analysis of extensively drug resistant Mycobacterium tuberculosis strains in Peru.
Research Article
Significance of the coexistence of non-codon 315 katG, inhA, and oxyR-ahpC intergenic gene mutations among isoniazid-resistant and multidrug-resistant isolates of Mycobacterium tuberculosis: a report of novel mutations.
Research Article
Novel mutation
A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.
Research Article
Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.
Research Article
Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.
Research Article
Mutations associated with isoniazid resistance.
Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022.
Research Article
Delayed culture conversion predicts poor outcomes for isoniazid mono-resistant TB in Uganda: a retrospective cross-sectional study from 2017- 2022.
Research Article
Effects of mutations in multiple Ethionamide-resistance-associated genes among Mycobacterium tuberculosis clinical isolates from China.
Research Article
Most prevalent mutation
Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.
Research Article
Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
Research Article
Comparative proteomic analysis of sequential isolates of Mycobacterium tuberculosis sensitive and resistant Beijing type from a patient with pulmonary tuberculosis.
Research Article
Genotypic distribution of multidrug-resistant and extensively drug-resistant tuberculosis in northern Thailand.
Research Article
Extensively drug resistant tuberculosis in Mali: a case report.
Research Article
Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.
Research Article
associated with Isoniazid resistance
Evaluation of the Xpert MTB/XDR test for detection of isoniazid, fluoroquinolones, and second-line injectable drugs resistance to Mycobacterium tuberculosis-Anhui Province, China.
Research Article
Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.
Research Article
Mutations in inhA are associated with isoniazid resistance.
Mutations conferring resistance to first- and second-line drugs in multidrug-resistant Mycobacterium tuberculosis clinical isolates in southeast Mexico.
Research Article
Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.
Review
Molecular Dynamics Assisted Mechanistic Study of Isoniazid-Resistance against Mycobacterium tuberculosis InhA.
Research Article
Mutations in InhA reduce NADH binding affinity, leading to isoniazid resistance.
Multidrug-Resistant Tuberculosis Complicated by Nosocomial Infection with Multidrug-Resistant Enterobacteriaceae.
Research Article
MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis.
Research Article
Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.
Research Article
Mutations in inhA gene contribute to isoniazid resistance.
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.
Research Article
Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.
Research Article
Confirmed in the study
Retrospective Analysis of Archived Pyrazinamide Resistant Mycobacterium tuberculosis Complex Isolates from Uganda-Evidence of Interspecies Transmission.
Research Article
First insights into the genetic characteristics and drug resistance of Mycobacterium tuberculosis population collected during the first national tuberculosis prevalence survey of Lao PDR (2010-2011).
Research Article
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB.
Research Article
Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance.
Review
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from south-central in China.
Research Article
mutations in the inhA gene are associated with isoniazid resistance
A multi-site validation in India of the line probe assay for the rapid diagnosis of multi-drug resistant tuberculosis directly from sputum specimens.
Research Article
Rapid detection of isoniazid resistance in Mycobacterium tuberculosis isolates by use of real-time-PCR-based melting curve analysis.
Research Article
Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hunan, China.
Research Article
A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.
Research Article
Performance of an Xpert-based diagnostic algorithm for the rapid detection of drug-resistant tuberculosis among high-risk populations in a low-incidence setting.
Research Article
Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.
Research Article
Mutations in inhA gene were identified in clinical isolates and laboratory strains.
A rapid identification technique for drug-resistant Mycobacterium tuberculosis isolates using mismatch specific cleavage enzyme.
Research Article
Mutations in inhA are associated with isoniazid resistance.
Rapid detection of multidrug resistant tuberculosis in respiratory specimens at a tertiary care centre in south coastal Karnataka using Genotype MTBDR plus assay.
Research Article
Common mutation in isoniazid resistant isolates
Isoniazid Resistance in Mycobacterium tuberculosis Is a Heterogeneous Phenotype Composed of Overlapping MIC Distributions with Different Underlying Resistance Mechanisms.
Research Article
Mutations in the promoter region and coding region of inhA contribute to isoniazid resistance.
Prevalence and genetic basis of first-line drug resistance of Mycobacterium tuberculosis in Ca Mau, Vietnam.
Research Article
The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development.
Review
S94A mutation disrupts hydrogen-bonding network
New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.
Research Article
Heteroresistance to rifampicin & isoniazid in clinical samples of patients with presumptive drug-resistant tuberculosis in Central India.
Research Article
The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples.
Research Article
Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.
Research Article
mutations in inhA are associated with isoniazid resistance
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.
Research Article
mutations
Use of a molecular diagnostic test in AFB smear positive tuberculosis suspects greatly reduces time to detection of multidrug resistant tuberculosis.
Research Article
Estimating fitness by competition assays between drug susceptible and resistant Mycobacterium tuberculosis of predominant lineages in Mumbai, India.
Research Article
Comparison of line probe assay with liquid culture for rapid detection of multi-drug resistance in Mycobacterium tuberculosis.
Research Article
Mutations in inhA gene confer resistance to isoniazid.
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.
Review
Mutation in inhA confers resistance to isoniazid and ethambutol
Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.
Research Article
Case 1
Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis.
Research Article
Detected in 40.9% of Brazilian and 10.5% of Mozambican isolates.
Effect of efflux pump inhibitors on the susceptibility of Mycobacterium tuberculosis to isoniazid.
Research Article
What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis.
Research Article
Evaluation of Whole-Genome Sequencing for Mycobacterial Species Identification and Drug Susceptibility Testing in a Clinical Setting: a Large-Scale Prospective Assessment of Performance against Line Probe Assays and Phenotyping.
Research Article
Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
Research Article
Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations.
Research Article
Mutations promoted from gene entry 'inhA' (model emitted mutations_found inside genes).
Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis.
Research Article
The S94A mutation in InhA reduces the effectiveness of INH-NAD inhibition.
Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.
Research Article
Artificial Intelligence and Machine learning based prediction of resistant and susceptible mutations in Mycobacterium tuberculosis.
Research Article
Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing.
Research Article
Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.
Research Article
Present in GC1 isolates.
A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis.
Research Article
Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.
Research Article
Mutation associated with isoniazid resistance.
Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania.
Research Article
Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data.
Research Article
Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis.
Research Article
Molecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.
Research Article
Tuberculosis drug resistance mutation database.
Research Article
Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.
Research Article
The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.
Review
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.
Research Article
MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.
Research Article
[Metastases to the mediastinal lymph nodes in a series of two-hundred-consecutive operations for primary lung cancer].
Research Article
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide; CARD accession: CARD:3004876
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide; CARD accession: CARD:3004876
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
Detection of novel mutations associated with independent resistance and cross-resistance to isoniazid and prothionamide in Mycobacterium tuberculosis clinical isolates.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
GenoType MTBDRplus assay for molecular detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis strains and clinical samples.
Research Article
Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.
Research Article
Combination of commercially available molecular assays and culture based methods in diagnosis of tuberculosis and drug resistant tuberculosis.
Research Article
All seven INH-resistant isolates demonstrated the same mutation in the promoter region of inhA gene (A-16G).
Association Between the Phenotype and Genotype of Isoniazid Resistance Among Mycobacterium tuberculosis Isolates in Thailand.
Research Article
Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.
Research Article
Mutations in the cofactor binding site of InhA reduce NADH affinity but have minimal effect on INH-NAD adduct affinity.
Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates/from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19.
Research Article
associated with isoniazid resistance
Drug resistance mutations and heteroresistance detected using the GenoType MTBDRplus assay and their implication for treatment outcomes in patients from Mumbai, India.
Research Article
Utility of Line Probe Assay for the Early Detection of Multidrug-Resistant Pulmonary Tuberculosis.
Research Article
First evaluation of an improved assay for molecular genetic detection of tuberculosis as well as rifampin and isoniazid resistances.
Research Article
Comparative evaluation of GenoType MTBDRplus line probe assay with solid culture method in early diagnosis of multidrug resistant tuberculosis (MDR-TB) at a tertiary care centre in India.
Research Article
Correlation between the BACTEC MGIT 960 culture system with Genotype MTBDRplus and TB-SPRINT in multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.
Research Article
Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa.
Research Article
Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
Research Article
Mutations in the inhA promoter region and structural gene were identified, including I21V and I21T.
Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen.
Research Article
Mutations in inhA are associated with isoniazid resistance.
Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis by Use of Real-Time PCR and High-Resolution Melt Analysis.
Research Article
First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America.
Research Article
Analytical and clinical performance characteristics of the Abbott RealTime MTB RIF/INH Resistance, an assay for the detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis in pulmonary specimens.
Research Article
Evaluation of genotype MTBDRplus assay for rapid detection of isoniazid and rifampicin resistance in Mycobacterium tuberculosis clinical isolates from Pakistan.
Research Article
Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad.
Research Article
Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.
Research Article
The Regulation of ManLAM-Related Gene Expression in Mycobacterium tuberculosis with Different Drug Resistance Profiles Following Isoniazid Treatment.
Research Article
Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.
Research Article
Direct detection from sputum for drug-resistant Mycobacterium tuberculosis using a CRISPR-Cas14a-based approach.
Research Article
Mutation detected in INH-resistant isolates.
Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.
Research Article
Promoter mutation
The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.
Research Article
Confers isoniazid and ethionamide resistance
Evaluation of microscopic observation drug susceptibility assay for diagnosis of multidrug-resistant tuberculosis in Viet Nam.
Research Article
Mutation in inhA promoter region
Assessment of a 96-Well Plate Assay of Quantitative Drug Susceptibility Testing for Mycobacterium Tuberculosis Complex in China.
Research Article
Xpert MTB/XDR: a 10-Color Reflex Assay Suitable for Point-of-Care Settings To Detect Isoniazid, Fluoroquinolone, and Second-Line-Injectable-Drug Resistance Directly from Mycobacterium tuberculosis-Positive Sputum.
Research Article
Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.
Research Article
Prevalence of katG and inhA mutations associated with isoniazid resistance in Mycobacterium tuberculosis clinical isolates in Cameroon.
Research Article
Mutations associated with resistance to rifampicin and isoniazid identified in strains of the Mycobacterium tuberculosis complex by GenoType MTBDRplus in Panama, 2015-2021.
Research Article
Development of multiplex assay for rapid characterization of Mycobacterium tuberculosis.
Research Article
Mutation in inhA promoter region (-15 C->T) leads to isoniazid resistance.
Molecular detection of rifampin and isoniazid resistance to guide chronic TB patient management in Burkina Faso.
Research Article
High-resolution melting curve analysis for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
Research Article
Mutation in inhA promoter region is associated with isoniazid resistance.
Detection of tuberculosis drug resistance: a comparison by Mycobacterium tuberculosis MLPA assay versus Genotype®MTBDRplus.
Research Article
Systematic Review of Mutations Associated with Isoniazid Resistance Points to Continuing Evolution and Subsequent Evasion of Molecular Detection, and Potential for Emergence of Multidrug Resistance in Clinical Strains of Mycobacterium tuberculosis.
Review
Molecular Determinants of Ethionamide Resistance in Clinical Isolates of Mycobacterium tuberculosis.
Research Article
High specificity but low sensitivity
Evaluation of the cobas MTB and MTB-RIF/INH assay in clinical samples for the detection of Mycobacterium tuberculosis in respiratory specimens.
Research Article
Detected in strain MP 2104
Tuberculous spondylitis in Russia and prominent role of multidrug-resistant clone Mycobacterium tuberculosis Beijing B0/W148.
Research Article
High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.
Research Article
The -15C→T mutation was the most common inhA promoter mutation found in the study.
Detection of multidrug-resistant Mycobacterium tuberculosis strains isolated in Brazil using a multimarker genetic assay for katG and rpoB genes.
Research Article
associated with isoniazid resistance
Multi-Fluorescence Real-Time PCR Assay for Detection of RIF and INH Resistance of M. tuberculosis.
Research Article
Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
Research Article
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.
Research Article
Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis.
Research Article
Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations.
Research Article
Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.
Research Article
Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.
Research Article
Promoter mutation in inhA gene associated with low-level isoniazid resistance.
Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity.
Research Article
Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis.
Research Article
mutation in inhA promoter leading to isoniazid resistance
Prevalence and molecular characterization of multidrug-resistant M. tuberculosis in Jiangxi province, China.
Research Article
Genomic characterization of MDR/XDR-TB in Kazakhstan by a combination of high-throughput methods predominantly shows the ongoing transmission of L2/Beijing 94-32 central Asian/Russian clusters.
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In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis.
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Promoter region mutations in inhA
A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.
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Consistent with phenotypic results
In vitro modeling of isoniazid resistance mechanisms in Mycobacterium tuberculosis H37Rv.
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Detected in passage 2
Molecular characterization of genetic mutations with fitness loss in pulmonary tuberculosis patients associated with HIV co-infection in Northwest Amhara, Ethiopia.
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Detected in INH-mono-resistant isolates
Tuberculosis-spoligo-rifampin-isoniazid typing: an all-in-one assay technique for surveillance and control of multidrug-resistant tuberculosis on Luminex devices.
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Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
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All inhA mutations were associated with a Ser315Thr mutation in katG except for 1 isolate in which katG did not amplify.
Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.
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High-resolution melting analysis for molecular detection of multidrug resistance tuberculosis in Peruvian isolates.
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Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains.
Research Article
Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.
Review
Promoter region mutation at position -15C/T is associated with low-level resistance to INH.
Xpert Mycobacterium tuberculosis/Rifampicin-Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications.
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Translating drug resistant tuberculosis treatment guidelines to reality in war-torn Kandahar, Afghanistan: A retrospective cohort study.
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Mutations in inhA were identified in 8 (9.9%) of patients.
Whole-genome sequencing of Mycobacterium tuberculosis from Cambodia.
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Associated with isoniazid resistance
The Hidden Epidemic of Isoniazid-Resistant Tuberculosis in South Africa.
Research Article
In vitro anti-mycobacterial activity of (E)-N'-(monosubstituted-benzylidene) isonicotinohydrazide derivatives against isoniazid-resistant strains.
Review
Mutation in the coding region of inhA
Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.
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Impact of isoniazid resistance-conferring mutations on the clinical presentation of isoniazid monoresistant tuberculosis.
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Dominant incidence of multidrug and extensively drug-resistant specific Mycobacterium tuberculosis clones in Osaka Prefecture, Japan.
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Frequency of multi-drug resistance and mutations in Mycobacterium tuberculosis isolates from Punjab state of India.
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Mutation in inhA gene for INH resistance
Drug Resistance Conferring Mutation and Genetic Diversity of Mycobacterium tuberculosis Isolates in Tuberculosis Lymphadenitis Patients; Ethiopia.
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One isolate had inhA MUT1 band developed without missing the WT probe
Multidrug-resistant tuberculosis: rapid detection of resistance to rifampin and high or low levels of isoniazid in clinical specimens and isolates.
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Use of the GenoType(R) MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda.
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Importance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistance.
Review
Diagnostic accuracy and usefulness of the Genotype MTBDRplus assay in diagnosing multidrug-resistant tuberculosis in Cameroon? a cross-sectional study.
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Prevalence and factors associated with multidrug-resistant tuberculosis in South India.
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Associations between Mycobacterium tuberculosis strains and phenotypes.
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Mutations in inhA gene associated with isoniazid resistance
Diagnostic Performance of the GenoType MTBDRplus and MTBDRsl Assays to Identify Tuberculosis Drug Resistance in Eastern China.
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Phenotypic and genotypic analysis of anti-tuberculosis drug resistance in Mycobacterium tuberculosis isolates in Myanmar.
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Primary Multidrug Resistant Tuberculosis and Utility of Line Probe Assay for Its Detection in Smear-Positive Sputum Samples in a Tertiary Care Hospital in South India.
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Evaluation of GenoType MTBDRplus for the detection of drug-resistant Mycobacterium tuberculosis on isolates from Karachi, Pakistan.
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mutation in the inhA promoter region
Isoniazid and Rifampin-Resistance Mutations Associated With Resistance to Second-Line Drugs and With Sputum Culture Conversion.
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The positivity rates and drug resistance patterns of Mycobacterium tuberculosis using nucleotide MALDI-TOF MS assay among suspected tuberculosis patients in Shandong, China: a multi-center prospective study.
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Genotypic and phenotypic drug resistance patterns of Mycobacterium tuberculosis isolated from presumptive pulmonary tuberculosis patients in Ethiopia: A multicenter study.
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Cross-Border Movement of Highly Drug-Resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010-2015.
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mutation in the promoter region leads to overexpression of the gene, resulting in isoniazid resistance
Genotypic Distribution and the Epidemiology of Multidrug Resistant Tuberculosis in Upper Northern Thailand.
Research Article
Mutations in the inhA promoter are associated with isoniazid resistance
Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance.
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InhA promoter region C-15T mutation
Epidemiology of isoniazid resistance mutations and their effect on tuberculosis treatment outcomes.
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Resistance of Mycobacterium tuberculosis to antibiotics in Lao PDR: first multicentric study conducted in 3 hospitals.
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The C15T mutation in the inhA promoter is associated with isoniazid resistance.
Genotype diversity of Mycobacterium isolates from children in Jimma, Ethiopia.
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The mutation at the inhA locus was associated with low-level resistance to isoniazid and ethionamide.
Drug Resistance of Mycobacterium tuberculosis Complex in a Rural Setting, Angola.
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Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.
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Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis in Mongolia.
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Molecular detection of multidrug resistance pattern and associated gene mutations in M. tuberculosis isolates from newly diagnosed pulmonary tuberculosis patients in Addis Ababa, Ethiopia.
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Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.
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Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.
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Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis.
Review
A comprehensive evaluation of a novel targeted-sequencing workflow for Mycobacterium species identification and anti-tuberculosis drug-resistance detection.
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not covered by TB Pro assay
Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana.
Research Article
A molecular platform for the diagnosis of multidrug-resistant and pre-extensively drug-resistant tuberculosis based on single nucleotide polymorphism mutations present in Colombian isolates of Mycobacterium tuberculosis.
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Targeted next-generation sequencing of Mycobacterium tuberculosis from patient samples: lessons learned from high drug-resistant burden clinical settings in Bangladesh.
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The catalogue of Mycobacterium tuberculosis mutations associated with drug resistance to 12 drugs in China from a nationwide survey: a genomic analysis.
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The performance of Xpert MTB/RIF and MTBDRplus within a Programmatic setting at TB Laboratory in Rio de Janeiro, Brazil.
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Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages.
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Mutations in inhA are associated with isoniazid resistance in MDR and pre-XDR strains.
A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic.
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Mixed infection and clonal representativeness of a single sputum sample in tuberculosis patients from a penitentiary hospital in Georgia.
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The mutation was identified in patient 9 and confirmed by sequencing.
Off-label evaluation of the BD MAX MDR-TB assay for rapid diagnosis of rifampicin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in a high-volume reference laboratory.
Research Article
Mutations in inhA promoter confer resistance to isoniazid
Multidrug-resistant Mycobacterium tuberculosis: a report of cosmopolitan microbial migration and an analysis of best management practices.
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Change in prevalence and molecular characteristics of isoniazid-resistant tuberculosis over a 10-year period in China.
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Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype-phenotype correlation.
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Molecular epidemiology of Mycobacterium tuberculosis, Buenos Aires, Argentina.
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Molecular detection and drug resistance of Mycobacterium tuberculosis complex from cattle at a dairy farm in the Nkonkobe region of South Africa: a pilot study.
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Assessment of the genotype MTBDRplus assay for rifampin and isoniazid resistance detection on sputum samples in Cote d'Ivoire.
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Whole-Genome Sequencing Has the Potential To Improve Treatment for Rifampicin-Resistant Tuberculosis in High-Burden Settings: a Retrospective Cohort Study.
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Genetic Identification and Drug-Resistance Characterization of Mycobacterium tuberculosis Using a Portable Sequencing Device. A Pilot Study.
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Mutation in inhA gene associated with isoniazid resistance.