Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding.

PMID: 179546902008

Key Findings

The study identifies mprF as a gene associated with daptomycin resistance in Staphylococcus aureus, showing that its deletion reduces daptomycin MICs and affects membrane properties.

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1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mprF	1	a gene which contributes to membrane charge through lysinylation of PG	Daptomycin	Staphylococcus aureus	Reslit	-

Browse Papers

Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding.

AMR Genes