Key Findings

Arcobacter butzleri strain RM4018 exhibits resistance to multiple antibiotics, including chloramphenicol, beta-lactams, macrolides, sulfonamides, quinolones, and 5-fluorouracil. Resistance to chloramphenicol is likely due to the presence of a cat gene encoding a chloramphenicol O-acetyltransferase. Beta-lactam resistance is possibly due to the presence of three putative beta-lactamases and the lrgAB operon. The absence of the upp gene contributes to high 5-fluorouracil resistance.