E240V Substitution Increases Catalytic Efficiency toward Ceftazidime in a New Natural TEM-Type Extended-Spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens Clinical Isolates.

PMID: 181605202008Italy

Key Findings

The study characterizes TEM-149, a new natural TEM-type extended-spectrum beta-lactamase with an E240V substitution that enhances catalytic efficiency towards ceftazidime, cefotaxime, and aztreonam.

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5gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaTEM	1	beta-lactamase	CeftazidimeCefotaximeAztreonamAZTREONAMTICARCILLINCEPHALOSPORINAMOXICILLINCEFEPIMEAMPICILLIN+4 more	Enterobacter aerogenes Serratia marcescens Escherichia coli Klebsiella aerogenes	Card DatabaseReference Gene CatalogResFinder Database

Browse Papers

E240V Substitution Increases Catalytic Efficiency toward Ceftazidime in a New Natural TEM-Type Extended-Spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens Clinical Isolates.

AMR Genes