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Key Findings
Mutations in rpoB are associated with rifampin and rifaximin resistance in C. difficile
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| rpoB | H502Y | - | - | Clostridium difficile | rifampin|rifaximin | Reslit | - |
| rpoB | H502N | - | - | Clostridium difficile | rifampin|rifaximin | Reslit | - |
| rpoB | H502R | - | - | Clostridium difficile | rifampin|rifaximin | Reslit | - |
| rpoB | R505K | - | - | Clostridium difficile | rifampin|rifaximin | Reslit | - |
| rpoB | S488T | - | - | Clostridium difficile | rifampin|rifaximin | Reslit | - |
| rpoB | I548M | - | - | Clostridium difficile | rifampin|rifaximin | Reslit | - |
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