Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus.

PMID: 186449672008

Key Findings

A point mutation in the two-component sensor gene graS (T136I) was identified as a major contributor to intermediate vancomycin resistance in clinical Staphylococcus aureus.

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1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
graS	1	two-component sensor histidine kinase	Vancomycin	Staphylococcus aureus	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
graS	T136I	-	-	Staphylococcus aureus	Vancomycin	Reslit	-

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Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus.

AMR Genes

AMR Mutations