Key Findings

The study characterizes the novel KPC variant KPC-5, which differs from KPC-2 by a single amino acid substitution (Pro 103 → Arg) and from KPC-4 by an additional amino acid change (Val 239 → Gly). KPC-5 shows distinct enzymatic properties compared to KPC-2 and KPC-4, including differences in isoelectric point and susceptibility to clavulanic acid inhibition.