Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein.

PMID: 193258772009

Key Findings

Inactivation of dacB leads to high-level β-lactam resistance.

0gene entries

3mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
dacB	T79P	-	inactivation	Pseudomonas aeruginosa	ceftazidime\|cefepime\|piperacillin\|imipenem	Reslit	-
dacB	T428P	-	inactivation	Pseudomonas aeruginosa	ceftazidime	Reslit	-
dacB	W273X	-	inactivation	Pseudomonas aeruginosa	ceftazidime\|cefepime\|piperacillin\|imipenem	Reslit	-