The fitness cost of streptomycin resistance depends on rpsL mutation, carbon source and RpoS (σS).

PMID: 196521792009

Key Findings

Mutations in rpsL are responsible for streptomycin resistance and have varying effects on bacterial fitness depending on environmental conditions.

0gene entries

9mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpsL	K42N	-	impairs ribosome performance	Escherichia coli, Mycobacterium tuberculosis, Salmonella enterica	streptomycin	Reslit	-
rpsL	P90S	-	impairs ribosome performance	Salmonella enterica, Escherichia coli, Mycobacterium tuberculosis	streptomycin	Reslit	-
rpsL	K42R	-	retains wild-type translation rate	Salmonella enterica, Escherichia coli, Mycobacterium tuberculosis	streptomycin	Reslit	-