Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.

PMID: 199630782010

Key Findings

All mutations are missense mutations in the pncA gene associated with pyrazinamide resistance.

0gene entries

29mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA	L4S	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	C14G	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	P54L	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	Q10R	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	T76P	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	L116P	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V7I	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G24D	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	K48T	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	H51R	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	W119L	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V139A	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	D12A	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	D49N	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	L85P	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	D136G	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	A134V	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	D12G	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G78C	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	H71Y	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	H137P	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	T142P	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	Y34D	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	P62L	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G105D	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V7F	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	F94L	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	T135P	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V155A	-	loss of PZAse activity	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-

Browse Papers

Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.

AMR Mutations