Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria.

PMID: 200076062010

Key Findings

The Cfr methyltransferase confers resistance to multiple antibiotics by methylating 23S rRNA at A2503. Mutagenesis studies identified critical residues for Cfr activity.

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1gene entry

22mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
cfr	1	methyltransferase	PhenicolLincosamideOxazolidinonePleuromutilinStreptogramin a	Escherichia coli Staphylococcus aureus	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
cfr	S212A	-	-	Escherichia coli	Florfenicol\|Tiamulin	Reslit	-
cfr	R25A	-	-	Escherichia coli	Florfenicol\|Tiamulin	Reslit	-
cfr	C116A	-	-	Escherichia coli	Florfenicol\|Tiamulin	Reslit

Browse Papers

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria.

AMR Genes

AMR Mutations