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Key Findings
Mutations in the beta subunit of RNA polymerase (rpoB) confer resistance to streptolydigin and streptovaricin in Streptomyces lydicus and Streptomyces spectabilis.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| A471S | - | - | Streptomyces spectabilis, Streptomyces lydicus | Streptovaricin|Rifampin | Reslit | - | |
| S475A | - | - | Streptomyces spectabilis, Streptomyces lydicus | Streptovaricin|Rifampin | Reslit | - | |
| T638K | - | - | Streptomyces lydicus, Streptomyces spectabilis | Rifampin | Reslit | - | |
| S470N | - | - | Streptomyces spectabilis, Streptomyces lydicus | Streptovaricin|Rifampin | Reslit | - | |
| L463I | - | - | Streptomyces lydicus, Streptomyces spectabilis | Streptovaricin|Rifampin | Reslit | - | |
| N474S | - | - | Streptomyces lydicus, Streptomyces spectabilis | Streptovaricin|Rifampin | Reslit | - | |
| A639S | - | - | Streptomyces lydicus, Streptomyces spectabilis | Rifampin | Reslit | - |
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