Key Findings

SigV, oatA, and dltA are involved in lysozyme resistance and virulence of Enterococcus faecalis. SigV plays a key role in the lysozyme resistance mechanism, and its deletion leads to increased sensitivity to lysozyme. OatA and dltA also contribute to lysozyme resistance, with their combined deletion causing the highest sensitivity. Additionally, SigV is crucial for the virulence of E. faecalis in both systemic and urinary tract infection models.