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Key Findings
Mutations in the pncA gene were identified by sequencing the pncA genes from all isolates in which pyrazinamide resistance was detected by any of the three methods.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| Q10R | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| V139A | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| L172P | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| T76P | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| K48T | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| F94C | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| T135P | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| V155G | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - |
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